Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.4 mg/m³
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 540
- Modified dose descriptor starting point:
- other: LC50
- Value:
- 5 090 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Not applicable
- AF for dose response relationship:
- 1
- Justification:
- No effects observed at the highest dose tested.
- AF for differences in duration of exposure:
- 18
- Justification:
- Assuming chronic exposure of the worker.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- No correction for caloric demand for inhalation.
- AF for other interspecies differences:
- 1
- Justification:
- Not needed.
- AF for intraspecies differences:
- 3
- Justification:
- Difference in sensitivity among workers.
- AF for the quality of the whole database:
- 10
- Justification:
- No repeated dose data available.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.93 mg/kg bw/day
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 2 160
- Modified dose descriptor starting point:
- other: LD50
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Not applicable
- AF for dose response relationship:
- 1
- Justification:
- No effects observed at the highest dose tested.
- AF for differences in duration of exposure:
- 18
- Justification:
- Assuming chronic exposure of the worker.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Allometric scaling rat to human.
- AF for other interspecies differences:
- 1
- Justification:
- Not needed.
- AF for intraspecies differences:
- 3
- Justification:
- Difference in sensitivity among workers.
- AF for the quality of the whole database:
- 10
- Justification:
- No repeated dose data available.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
See the CSR for more details.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.7 mg/m³
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 900
- Modified dose descriptor starting point:
- other: LC50
- Value:
- 5 090 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Not applicable
- AF for dose response relationship:
- 1
- Justification:
- No effects observed at the highest dose tested.
- AF for differences in duration of exposure:
- 18
- Justification:
- Assuming chronic exposure of the worker.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- No correction for caloric demand for inhalation.
- AF for other interspecies differences:
- 1
- Justification:
- Not needed.
- AF for intraspecies differences:
- 5
- Justification:
- Difference in sensitivity among individuals.
- AF for the quality of the whole database:
- 10
- Justification:
- No repeated dose data available.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.56 mg/kg bw/day
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 3 600
- Modified dose descriptor starting point:
- other: LD50
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Not applicable
- AF for dose response relationship:
- 1
- Justification:
- No effects observed at the highest dose tested.
- AF for differences in duration of exposure:
- 18
- Justification:
- Assuming chronic exposure of the worker.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Allometric scaling rat to human.
- AF for other interspecies differences:
- 1
- Justification:
- Not needed.
- AF for intraspecies differences:
- 5
- Justification:
- Difference in sensitivity among individuals.
- AF for the quality of the whole database:
- 10
- Justification:
- No repeated dose data available.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.56 mg/kg bw/day
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC guidance (Technical Report No. 110, October 2010)
- Overall assessment factor (AF):
- 3 600
- Modified dose descriptor starting point:
- other: LD50
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Not applicable
- AF for dose response relationship:
- 1
- Justification:
- No effects observed at the highest dose tested.
- AF for differences in duration of exposure:
- 18
- Justification:
- Assuming chronic exposure of the worker.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Allometric scaling rat to human.
- AF for other interspecies differences:
- 1
- Justification:
- Not needed.
- AF for intraspecies differences:
- 5
- Justification:
- Difference in sensitivity among individuals.
- AF for the quality of the whole database:
- 10
- Justification:
- No repeated dose data available.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
See the CSR for more details.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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