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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal
Justification for type of information:
Data is from peer reviewed journal
Qualifier:
according to guideline
Guideline:
other: Refer below principle
Principles of method if other than guideline:
Short term toxicity of test chemical were evaluated by observing the effects of chemical on the ability to detach from substrate of Dreissena polymorpha
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other aquatic mollusc: Dreissena polymorpha
Details on test organisms:
SPECIES (NAME) : Dreissena polymorpha (Zebra Mussel)
Organism Characteristics : 5-8 MM SHELL LENGTH
Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Hardness:
146(136-156) milligrams per liter Calcium ca
Test temperature:
17(16.3-17.4)°Celsius
pH:
8 (7.3-8.7)
Dissolved oxygen:
8.3(6-11.2) milligrams per liter
Nominal and measured concentrations:
2.8-4 mg/L
Details on test conditions:
TEST LOCATION : LAB
Water Conductivity : 260(212-298) micro ohms per centimeter
Water Alkalinity : 109(98-120) milligrams per liter Calcium ca
Reference substance (positive control):
not specified
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
3.4 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
behaviour
Remarks:
Ability to detach from substrate
Remarks on result:
other: 3.4(2.8-4) mg/L
Validity criteria fulfilled:
no
Conclusions:
The 48 hour EC50 value of test chemical in invertebrate (Dreissena polymorpha) was determine to be 3.4 mg/L on the basis of effect on ability to detach from substrate.
Executive summary:

Short term toxicity of test chemical were evaluated by observing the effects of chemical on the ability to detach from substrate. Test conducted under the static system on 5-8 MM shell length of Dreissena polymorpha. The 48 hour EC50 value of test chemical in invertebrate (Dreissena polymorpha) was determine to be 3.4 mg/L on the basis of effect on ability to detach from substrate. This value indicates that the chemical will exhibit short term toxicity to invertebrates. As per the CLP criteria, this classification amounts to Aquatic Chronic Category 2.

Description of key information

Short term toxicity of test chemical were evaluated by observing the effects of chemical on the ability to detach from substrate. Test conducted under the static system on 5-8 MM shell length of Dreissena polymorpha. The 48 hour EC50 value of test chemical in invertebrate (Dreissena polymorpha) was determine to be 3.4 mg/L on the basis of effect on ability to detach from substrate. This value indicates that the chemical will exhibit short term toxicity to invertebrates. As per the CLP criteria, this classification amounts to Aquatic Chronic Category 2.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
3.4 mg/L

Additional information

Summarized result for the toxicity of test chemical on the mobility of aquatic invertebrates were reviewed and mention as below:

Short term toxicity of test chemical were evaluated by observing the effects of chemical on the ability to detach from substrate. Test conducted under the static system on 5-8 MM shell length of Dreissena polymorpha. The 48 hour EC50 value of test chemical in invertebrate (Dreissena polymorpha) was determine to be 3.4 mg/L on the basis of effect on ability to detach from substrate. This value indicates that the chemical will exhibit short term toxicity to invertebrates. As per the CLP criteria, this classification amounts to Aquatic Chronic Category 2.

 

Above study was supported by the second experimental study from peer reviewed journal. Short term toxicity of test chemical were studied on the mobility of daphnia magna. The 48 hour EC50 value of test chemical in Daphnia magna was determine to be 2.3 mg/L on the basis of mobility. This value indicates that the chemical will exhibit short term toxicity to fish. As per the CLP criteria, this classification amounts to Aquatic Chronic Category 2.

 

Objective of the present study was to evaluate the effect of chemical on aquatic mollusc Dreissena polymorpha. The effective concentration (EC50) value of test chemical in aquatic mollusc [zebra mussels (Dreissena polymorpha)] in a 48 hr study on the basis of effect on attachment was consider to be in the range 19.4 to 29 mg/L. Thus based on the above effects observation, chemical consider to be toxic and classified as aquatic chronic 3 as per the CLP classification criteria.

 

Similar short term toxicity of test chemical were evaluated by observing the effects of chemical on the aquatic mollusc. The lethal concentration (LC50) value of test chemical in Dreissena polymorpha in a 48 hr study on the effect basis of mortality was observed to be 65 mg/L. Thus based on the above effects observation, chemical consider to be toxic and classified as aquatic chronic 3 as per the CLP classification criteria.

 

Based on the above two studies, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.