Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-442-7 | CAS number: 121-00-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Dose No.: B244
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE):Furia, T. E. (Ed.) CRC Handbook of Food Additives 2nd ed., 1972, Chemical Rubber Co., Cleveland, OH.
- Reference Type:
- other: Authoritative data base
- Title:
- NTP study for 25013-16-5
- Author:
- NTP Database
- Year:
- 2 012
- Bibliographic source:
- NTP (National Toxicological Program)by Agency for Toxic Substances and Disease Registry; Division of Toxicology/Toxicology Information Branch, 1600 Clifton Road NE, E-29, Atlanta, Georgia 30333
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from NTP database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-tert-butyl-4-methoxyphenol
- EC Number:
- 204-442-7
- EC Name:
- 2-tert-butyl-4-methoxyphenol
- Cas Number:
- 121-00-6
- Molecular formula:
- C11H16O2
- IUPAC Name:
- 2-tert-butyl-4-methoxyphenol
- Details on test material:
- - Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50 mg of tert-butyl-4-methoxyphenol (BHA)
- Control animals:
- not specified
Results and discussion
Main ADME results
- Type:
- excretion
- Results:
- 27-77% was excreted in the urine
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- 27-77% was excreted in the urine as the glucuronide and urinary metabolites.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- glucuronide and urinary metabolites.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
When male human volunteers were given an oral dose of 50 mg tert-butyl-4-methoxyphenol (BHA), 27-77% was excreted in the urine as the glucuronide and urinary metabolites. - Executive summary:
When male human volunteers were given an oral dose of 50 mg tert-butyl-4-methoxyphenol (BHA), 27-77% was excreted in the urine as the glucuronide and urinary metabolites.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
