Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 262-872-0 | CAS number: 61617-00-3
In a 5 day preliminary hydrolysis study, ZMB2 showed <10% hydrolysis with an equivalent half life of >1 year at 25 deg C. ZMB2, therefore, is not expected to hydrolyse within the environmental compartment (Harlan Laboratories, 2013).
When considering the results of the investigations carried out to support the read-across from 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione (MB2) to 2H-Benzimidazole-2-thione, 1,3-dihydro-4(or 5)-methyl-, zinc salt (2:1) (ZMB2) (LANXESS, 2018), the results of the hydrolysis as a function of pH study conducted with this substance must be reconsidered in light of new information. The overall conclusion in LANXESS (2018) is that ZMB2 exhibits its salt characteristic in aqueous solution, i.e., dissolving in water to MB2 and zinc ions in a matter of seconds. For full details of the investigations conducted relating to hydrolysis, refer to Section 13.2 of IUCLID.
In the HPLC-UV analysis performed in this study, a mobile phase consisting of acetonitrile:water (30:70 v/v) was applied. Under these aqueous conditions, based on the weight of evidence presented in this document, it is clear that ZMB2 will instantly dissociate to MB2 (LANXESS, 2018). Thus in this study it would not have been possible to detect ZMB2 in undissociated form, only MB2 was observable at pHs 4-9.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again