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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A study which conformed to the basic requirements of the relevant OECD guideline. There are some doubts over substance identity, but since the result of the study was negative, it is considered to contribute to the overall dataset as any impurities themselves must have been non irritant.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-ethoxyethoxy)ethanol
EC Number:
203-919-7
EC Name:
2-(2-ethoxyethoxy)ethanol
Cas Number:
111-90-0
Molecular formula:
C6H14O3
IUPAC Name:
2-(2-ethoxyethoxy)ethan-1-ol
Constituent 2
Reference substance name:
2-(2'-ethoxyethoxy)ethanol
IUPAC Name:
2-(2'-ethoxyethoxy)ethanol
Details on test material:
- Name of test material (as cited in study report): Carbitol solvent, low gravity
- Lot/batch No.: TS-590110; Log #1701

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5ml
Duration of treatment / exposure:
0.5 ml for 4 hr occlusive patch test.
Observation period:
7 days
Number of animals:
3 female and 3 male
Details on study design:
The dose is applied to the clipped, intact skin under a gauze patch and is loosely covered with impervious sheeting.
The test material is applied to each of 6 rabbits, which are restrained for the 4-hr contact period.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Time point:
other: 5 hrs, 1, 2, 3, and 7 days
Score:
0
Max. score:
4
Remarks on result:
other: Erythema and eschar formation
Irritation parameter:
edema score
Time point:
other: 5 hrs, 1 day, 2 days, 3 days, and 7 days
Score:
0
Max. score:
4
Irritant / corrosive response data:
No irritation was induced

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test substance is of low dermal irritation potential
Executive summary:

In a reasonably well reported study, rabbits were exposed to 0.5ml of 2 -(2 -ethoxyethoxy)ethanol dermally under occlusion for 4 hours. The skin was examined for erythema and edema at 1 hr, one day, 2 days, 3 days and 7 days. The test substance did not induce any irritation score and therefore it is mildly irritant.