2-(2-ethoxyethoxy)ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given, sufficient to be able to judge the results as reliable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

This test (also called inhalation risk test) was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (20 °C).

GLP compliance:

not specified

Test type:

other: Inhalation risk test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-ethoxyethoxy)ethanol

EC Number:

203-919-7

EC Name:

2-(2-ethoxyethoxy)ethanol

Cas Number:

111-90-0

Molecular formula:

C6H14O3

IUPAC Name:

2-(2-ethoxyethoxy)ethan-1-ol

Details on test material:

- Name of test material (as cited in study report): Ethyldiglykol

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

Young adult laboratory rats were purchased from a breeder. In general, the source and strain of the animals were not documented.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: 200 l/hour
- Temperature, humidity, pressure in air chamber: 20°C
- 12 rats were exposed to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours. The exposure time not causing lethality was usually tested twice.
- No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually can be calculated as quotient of the amount of test substance weight loss during the exposure, which is given in the raw data, and the amount of air used during the exposure.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

0.025 mg/l

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 1 day
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology
- Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals.
The clinical signs and findings were reported in summarized form.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.025 mg/L air

Exp. duration:

8 h

Remarks on result:

other: vapour

Mortality:

no death occured

Clinical signs:

other: moderate attempts to escape; slight eye discharge

Body weight:

no data

Gross pathology:

nothing abnormal detected

Other findings:

none

Any other information on results incl. tables

No mortality was observed when 12 rats were treated with the test substance for 8 hours.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Executive summary:

In an inhalation hazard test that followed the basic principles of a guideline acute inhalation toxicity test, male and female rats were subjected to a 'saturated' atmosphere of 2 -(2 -ethoxyethoxy)ethanol, characterised as 25mg/m3, for a period of 8 hours. No deaths were reported.