Prop-2-yn-1-ol

Endpoint summary

Description of key information

The LD50/LC50 values derived form the key-studies were: LD50 (oral, rat)  56.4 mg/kg bw,  LD50 (dermal, rabbit) 88 mg/kg bw,  LC50 (2 h inhalation, rat) 2000 mg/m³.  Based on these results, propargyl alcohol is considered to be toxic following acute oral, dermal or inhalation exposure.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

56.4 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Dose descriptor:

LC50

Value:

2 000 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

88 mg/kg bw

Additional information

The acute oral toxicity of Propargyl alcohol in the rat was examined in many studies.

The BASF study from 1963, where a LD50 of 56.4 mg/kg bw was derived, has been identified as key-study. This study represents the most reliable study as a reliable source of test material was used and the test was done according to a well described BASF method which was in compliance with the principles of OECD Guideline 401. Agitation, hyperventilation and prone position of animals were noticed as clinical sings after application. The LD50 value is supported by additional data, where LD50 values of 50 – 145 mg/kg bw were reported in the rat (Stasenkova and Kochetkova, 1966; Vernot et al., 1977, BASF Toxicology Department, 1967; Archer, 1986).

The LD50 values in the mouse were ca. 50 mg/kg body weight (Stasenkova and Kochetkova, 1966; Burton, 1964)

 

In an acute dermal toxicity study using female rabbits the LD50 was 88 mg/kg bw (Vernot, 1977). This is the most reliable study as it is well documented and was done in compliance with the principles of OECD Guideline 402.

 

In the acute inhalation toxicity study by Stasenkova and Kochetkova (1966), groups of 10 rats were exposed via the inhalation route to Propargyl alcohol at nominal concentration of 3, 5, 10, 15 and 20 mg substance/l for 2 hours. Animals exposed to high concentrations showed quickly after beginning of exposure mucous membrane irritation, apathy, dyspnoea and lateral position (lying on the side). The inhalation LC50 in the rat was 2000 mg/m³ for an exposure period of 2 hours. This is the most reliable study as it is well documented and was done in compliance with the principles of OECD Guideline 403.

This LC50 value is supported by additional data (Vernot et al., 1977), where LC50 values of 2750 mg/m³ (male rats) and 2420 mg/m³ (female rats) were derived from studies with 1 h exposure.

Justification for classification or non-classification

Based on the results for acute oral (LD50 rat 56 mg/kg bw), acute dermal (LD50 rabbit 88 mg/kg bw) and inhalation toxicity (LC50 rat (2h) 2 mg/L) Propargyl alcohol is classified for acute toxicity as follows:

acute toxicity: cat. 3, H301, toxic if swallowed; cat. 2, H310, fatal in contact with skin; cat. 2, H330, fatal if inhaled (according to Regulation 1272/2008/EC)