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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1966
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was performed prior to the implementation of GLP and OECD Guidelines, but is in compliance with the principles described in OECD Guideline 403.

Data source

Reference
Reference Type:
publication
Title:
Toxikologische Charakteristik von Propargylalkohol (German translation from Russian)
Author:
Stasenkova KP, Kochetkova TA
Year:
1966
Bibliographic source:
Toksikol. Nov. Prom. Khim. Veshchestv. 8, 97 - 111

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
, animals were exposed to the test concentration for 2 hours, however, the study was performed prior to OECD GL 403
GLP compliance:
no
Remarks:
, test predated GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Prop-2-yn-1-ol
EC Number:
203-471-2
EC Name:
Prop-2-yn-1-ol
Cas Number:
107-19-7
Molecular formula:
C3H4O
IUPAC Name:
prop-2-yn-1-ol
Details on test material:
- pure test substance

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not indicated

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: test chamber
- Exposure chamber volume: 107 L
- Method of conditioning air: vapours were evenly distributed using an appropriate mixer
- System of generating particulates/aerosols: Test substance was placed on filter paper and evaporated in the test chamber





Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
2 h
Concentrations:
Nominal values:
3, 5, 10, 15, 20 mg/l
After 120 minutes:
0.3, 1.0, 1.6, 3.0, 6.6 mg/l
No. of animals per sex per dose:
10 per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 3 days (animals survived)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
2 000 mg/m³ air
Mortality:
After 120 min treatment 100% mortality at 6.6 mg/l and 3 mg/l,
50% mortality at 1.6 mg/l,
10% mortality at 1.0 mg/l and
no mortality at 0.3 mg/l.
Clinical signs:
other: Mucous membrane irritation, apathy, dyspnoea, lateral position (lying on the side)
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Executive summary:

In an acute inhalation toxicity study, groups of 10 rats were exposed via the inhalation route to Propargyl alcohol in a nominal concentration of 3, 5, 10, 15, 20 mg substance/l for 2 hours. Animals exposed to high concentrations showed quickly after beginning of exposure mucous membrane irritation, apathy, dyspnoea and lateral position (lying on the side). The inhalation LC50 Rat was estimated as 2000 mg/m3.