Registration Dossier
Registration Dossier
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EC number: 204-661-8 | CAS number: 123-91-1
Endpoint summary
Administrative data
Description of key information
Experimental data are only available for one trophic level. Based on seed germination an EC50 (3 d) of 1450 mg/L (corresponds to 2175 mg/kg soil dw) for Lactuca sativa was observed. No further studies on terrestrial organisms are available for 1,4-dioxane (CAS 123-91-1).
Additional information
Experimental data are only available for one trophic level. Based on seed germination an EC50 (3 d) of 1450 mg/L (corresponds to 2175 mg/kg soil dw) for Lactuca sativa was observed. No further studies on terrestrial organisms are available for 1,4-dioxane (CAS 123-91-1).
In Annex X section 9.4 of Regulation (EC) No 1907/2006, it is laid down that tests on terrestrial organisms shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on terrestrial organisms. The choice of the appropriate tests depends on the outcome of the chemical safety assessment. In particular for substances that have a high potential to adsorb to soil or that are very persistent, the registrant shall consider long-term toxicity testing instead of short-term. According to Annex X section 9.4 of Regulation (EC) No 1907/2006, those studies do not need to be conducted if direct or indirect exposure of the soil compartment is unlikely.
The available data indicate that the substance is not very adsorptive (log Koc < 3; see IUCLID chapter 5.4.1) or bioaccumulative (mean BCF = 0.45; measured, see IUCLID chapter 5.3.1). Furthermore, the substance’s distribution modelling indicates that the main target for environmental distribution will be water (see IUCLID chapters 5.4.3). Therefore, exposure of terrestrial organisms is unlikely.
In addition, the substance is not a PBT or vPvB substance and the risk assessment results in Risk Characterization Ratios (RCRs) far below 1 for all compartments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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