Registration Dossier
Registration Dossier
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EC number: 204-661-8 | CAS number: 123-91-1
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish: With high probability acutely not harmful to fish.
Key study:OECD 204 prolonged study, Oryzias latipes (NITE, J-Check database, Japan, data published)
- 21-d LC50 > 100 mg/L (nom., analytically verified)
Supp. Study:No guideline followed, method by Dawson, saltwater, Menidia beryllina (Dawson, 1975, data published)
- 96-h LC50 =6700 mg/L (nom.)
Supp. Study:-No guideline followed, special acute fish toxicity test system by the Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Pimephales promelas (Geiger, 1990, Test 1, 2, rep. no.: 0-9614968-5-1).
96-h LC50 = 9850 mg/L (nom., analytically verified, Test 1)
96-h LC50 = 10800 mg/L (nom., analytically verified, Test 2)
Supp. Study: similar to OECD 203, Pimephales promelas (Dow Chemical, TSCAT, 1989, rep. no.: ES-DR-0000-9529-4),
96-h LC50 = 13000 mg/L (nom., analytically verified)
Long-term toxicity data to fish:
Key study: similar OECD 210, Pimephales promelas (Dow Chemical, TSCAT, 1989, rep. no.: ES-DR-0000-9529-4):
32-d NOEC = 145 mg/L (measured initial, in agreement with the nominal concentrations)
Short term toxicity to aquatic invertebrates:With high probability acutely not harmful to aquatic invertebrates.
Key study: OECD 202, Daphnia magna (NITE, J-Check database, Japan, data published):
48-h EC50 > 1000 mg/L (nom., analytically verified)
Long-term toxicity to aquatic invertebrates:
Key study: OECD 2011, Daphnia magna (NITE, J-CHECK databank, published data):
21-d NOEC = 1000 mg/L (nominal)
Other information:
Method 1002.0 (EPA 1989), Ceriodaphnia dubia (TSCAT, 1989, rep. no.: OTS0516624-6):
NOEC =625 mg/L (measured)
Toxicity to aquatic algae and cyanobacteria: With high probability acutely not harmful to aquatic algae.
Key study:OECD 201, Desmodesmus subspicatus (NITE, J-CHECK databank, published data, 2016) :
72-h ErC50 > 1000 mg/L (nom., analytically verified)
72-h NOErC = 580 mg/L (nom., analytically verified)
Supp. Study:ISO 8692 (Fresh Water Algal Growth Inhibition Test), Scenedesmus quadricauda
- Bringmann&Kühn, 1977
8-d ErC5 = 5600 mg/L (nom.)
- Bringmann&Kühn, 1978
8-d EbC5 = 575 mg/L (nom.)
Toxicity to aquatic microorganisms: The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key study: Bringmann&Kühn, DIN 38412-8 Pseudomonas putida, 1977:
16-h ErC5 = 2700 mg/L (nominal)
Supp. study: ISO 8192, Activated sludge, industrial (BASF AG, 1979, report no.: 760):
30-min EC10 > 2000 mg/L (nominal)
Conclusion: Based on the available experimental data for the substance is considered to be with high probability acutely not harmful to aquatic organisms.
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