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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: only short documentation

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: no data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylamide
EC Number:
201-202-3
EC Name:
Methacrylamide
Cas Number:
79-39-0
Molecular formula:
C4H7NO
IUPAC Name:
methacrylamide
Test material form:
solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Duration of exposure:
4 hrs
Doses:
20% or 10% solutions
No. of animals per sex per dose:
10
Control animals:
yes
Details on study design:
In this study, 20% or 10% solution of methacrylamide was applied for 4 hours to abdominal skin.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LDLo
Remarks:
4 hours application
Effect level:
> 1 600 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Executive summary:

In an acute dermal toxicity study 10 rats per dose group were dermally exposed to 20- and 10-% solutions of Methacrylamide in 60% ethanol, (96 %, denatured with 2 % Benzene) 20 % Propanol and 20 % water for 4 hours to 10 % of body surface area. No mortality occured. Only temporary apathie just like the control group with the vehicle was observed.

Dermal LD0 > 1600 mg/kg

Methacrylamide is of low toxicity