Registration Dossier
Registration Dossier
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EC number: 215-150-4 | CAS number: 1306-38-3
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to birds
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
Data waiving (other justification):
When there is no avian toxicity data available, the ECHA Guidance on Information Requirements and Chemical Safety Assessment - Chapter R.7C (p. 100) indicates that testing may be required if both following conditions are fulfilled: (1) the substance has a potential for contaminating food chains, AND, (2) there is evidence of toxicity in mammalian repeat dose or reproduction test. In the case of cerium dioxide, the bioaccumulation potential is low based on the analogy made with soluble salts of cerium. As a result, secondary poisoning via the food chains is unlikely. Furthermore, according to IUCLID sections 7.5 and 7.8, no relevant signs of toxicity were observed during reproduction test (neither developmental, nor reproductive toxicity) or repeated-dose test via oral route. None of the above mentionned conditions are thus fulfilled. On this basis and according to column 2 of REACH Annex X, avian testing is not required for cerium dioxide.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
