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EC number: 265-155-0
CAS number: 64742-52-5
A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and produces a finished oil of at least 100 SUS at 100°F (19cSt at 40°C). It contains relatively few normal paraffins.
In an acute dermal toxicity study, API 78-9
was administered to 4 New Zealand White rabbits/sex at a dose of 5000
mg/kg for 24 hours. Prior to application of the test material the
exposure sites of four rabbits were abraded by making epidermal
incisions. The remaining four rabbits were left unbraded. Another group
of eight (4/sex) rabbits were used as control animals.
Behavioral reactions were monitored through
the 24 -hour contact period. Mortality, clinical signs of toxicity, and
behavioral abnormalities were observed for twice daily through the 14
-daypost exposure observation period. Body weight was recorded for all
animals on Day 0, 7, and 14 of the study period. On Day 14 all animals
were necropsied and observed for gross pathological changes.
Dermal administration of API 78-9 at 5000
mg/kg did not result in any dermal irritation or signs of clinical
toxicity. Gross necroscopy did not reveal any signs of systemic toxicity
at the 5000 mg/kg dose level.
The acute dermal LD50 for API
78-9 is >5000 mg/kg
This study is classified as reliable without
restriction because it was conducted according to OECD guideline 402.
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