Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 231-635-3 | CAS number: 7664-41-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- review article
- Principles of method if other than guideline:
- review article
- GLP compliance:
- no
- Dose descriptor:
- other: not relevant; see remark
- Nominal / measured:
- nominal
- Conc. based on:
- other: not relevant; see remark
- Basis for effect:
- other:
- Remarks on result:
- other: The presented values are NOT relevant for the risk assessment. Using IUCLID 6.5.15 (most recent version at dossier preparation), the CSR generator does not accept empty fields.
- Remarks:
- See details on results
- Details on results:
- Ammonia is generated as a product of metabolism by bacteria present in STPs from other sources including nitrogenous waste. STPs will therefore contain ammonia generated by bacteria from other sources at potentially much higher levels. Ammonium is readily converted by bacterial species to nitrate, via the process of nitrification. The primary stage of nitrification, the oxidation of ammonium to nitrite (NO2-) is performed by Nitrosomonas (among other) species. Other bacterial species (including Nitrobacter) are responsible for the subsequent oxidation of nitrite to nitrate (NO3-).
Reference
Description of key information
Ammonia is used as a source of nitrogen by microorganisms and is also produced by bacteria from other nitrogenous compounds. A waiver is therefore proposed for this endpoint as testing is not relevant.
Key value for chemical safety assessment
Additional information
Ammonia is generated as a product of metabolism by bacteria present in STPs from other sources including nitrogenous waste. STPs will therefore contain ammonia generated by bacteria from other sources at potentially much higher levels. Ammonium is readily converted by bacterial species to nitrate, via the process of nitrification. The primary stage of nitrification, the oxidation of ammonium to nitrite (NO2-) is performed by Nitrosomonas (among other) species. Other bacterial species (including Nitrobacter) are responsible for the subsequent oxidation of nitrite to nitrate (NO3-).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
