Registration Dossier
Registration Dossier
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EC number: 231-915-5 | CAS number: 7778-80-5
Toxicity to birds
Administrative data
- Endpoint:
- short-term toxicity to birds: dietary toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited information provided
Data source
Reference
- Reference Type:
- publication
- Title:
- Benefit from the supplementation of K2SO4 or K2-MgSO4 to the diet of turkey poults.
- Author:
- Miles, R.D. and Harms, R.H.
- Year:
- 1 983
- Bibliographic source:
- Nutrition Reports International 28(2):381-384.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium sulfate (K2SO4)
- IUPAC Name:
- Potassium sulfate (K2SO4)
- Reference substance name:
- Potassium magnesium sulfate (K2-MgSO4)
- IUPAC Name:
- Potassium magnesium sulfate (K2-MgSO4)
- Details on test material:
- Potassium sulfate (K2SO4), Potassium magnesium sulfate (K2-MgSO4)
Constituent 1
Constituent 2
- Dose method:
- feed
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on preparation and analysis of diet:
- The basal diet was deficient in sulfur amino acids. Treatments included no supplemental sulfate, 0.1% (1000 ppm) of K2SO4 and 0.1% K2-MgSO4. Supplemental methionine was 0, 0.1, and 0.15%.
Test organisms
- Test organisms (species):
- other: Nicholas Large White turkey poults
- Details on test organisms:
- Turkey poults were fed experimental diets from 0 to 21 days of age.
Study design
- Total exposure duration (if not single dose):
- 21 d
- Post exposure observation period:
- no data
- No. of animals per sex per dose and/or stage:
- 288 poults were assigned to 36 pens
- Nominal and measured doses / concentrations:
- 0.1% (1000 ppm) of K2SO4 and 0.1% K2-MgSO4.
- Details on test conditions:
- At day one a total of 288 poults were assigned to 36 pens. Individual body weights were obtained at 21 days of age and food consumed during the experiment was measured.
Examinations
- Details on examinations and observations:
- weight
- Reference substance (positive control):
- not specified
Results and discussion
Effect levels
- Duration (if not single dose):
- 21 d
- Dose descriptor:
- NOEC
- Effect level:
- > 1 000 other: mg/L
- Basis for effect:
- body weight
- Mortality and sub-lethal effects:
- The addition of K2SO4 to diets without supplemental methionine resulted in significantly increased body weight, but did not influence feed efficiency. The addition of either K2SO4 or K2-MgSO4 to the diet containing 0.1% methionine resulted in a further increase in growth compared to the unsupplemented control diet, indicating that they can spare a portion of the sulfur amino acid requirement in the diet of turkey poults.
Applicant's summary and conclusion
- Conclusions:
- NOEC > 1000 mg/L
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