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EC number: 204-000-3 | CAS number: 112-72-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies in detoxication 46 The metabolism of aliphatic alcohols. The glucuronic acid conjugation of acyclic aliphatic alcohols.
- Author:
- Kamil I A et al
- Year:
- 1 953
- Bibliographic source:
- Biochem 53:129-136
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- These studies were carried out to determine the extent to which various monohydric aliphatic alcohols, including C6-C18 alcohols included in this
category, form glucuronic acid conjugates in the rabbit. The excretion of glucuronic acids was determined daily in the urine for a week prior to administration of the test compound to establish a base line.
Following dosing the urine was collected for 24 hours and the glucuronides extracted. The results were reported as the amount of extra glucuronic acid excreted as a % of dose. - GLP compliance:
- no
Test material
- Reference substance name:
- Decan-1-ol
- EC Number:
- 203-956-9
- EC Name:
- Decan-1-ol
- Cas Number:
- 112-30-1
- Molecular formula:
- C10H22O
- IUPAC Name:
- decan-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Chinchilla
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- One dose
Doses / concentrations
- Dose / conc.:
- 25 other: m-moles/rabbit
- No. of animals per sex per dose / concentration:
- 2 animals in total (sex not specified)
- Control animals:
- no
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- All the primary alcohols investigated form glucuronic acid conjugates which are excreted in the urine. However this was generally <10% of the dose. For decan-1-ol this was 3.5% glucuronic acid excreted as % of dose (average of 2 rabbits).
Any other information on results incl. tables
The extra glucuronide excreted as % of dose (average of 3 rabbits, 2 rabbits for *) was as follows:
n-hexanol 10.3%; n-heptanol 5.3%; n-octanol 9.5%; n-nonanol 4.1%; n-decanol* 3.5%; n-octadecanol* 7.6%. It was reported that absorpton of
n-decanol and n-octadecanol was incomplete and irregular and the alcohol could be isolated in quantity from the faeces.
In addition in the case of n-decanol extra
glucuronic acid appeared in the urine on the second day after dosing
(whereas in most cases the excretion of extra glucuronic acid after
dosing was complete within 24 hours.
No further information on other biotransformation pathways of these alcohols was provided.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: no bioaccumulation potential based on study results
All the primary alcohols investigated form glucuronic acid conjugates which are excreted in the urine. However this was generally <10% of the dose.
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