Tetradecanol

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-10-02

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Test procedure in accordance with national standard methods (ASTM) without GLP.

Qualifier:

according to guideline

Guideline:

other: ASTM E 1148

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

1.3 mg/L

Temp.:

23 °C

pH:

5.5

Remarks on result:

other: Standard Deviation for these Data : +/- 0.6 mg/L

Measurement

(triple determination)

Results: 1.5 mg/L / 1.0 mg/L / Not Detected

Mean Concentration in Water: 1.0 mg/L

Standard Deviation for These Data: ±0.6 mg/L

Conclusions:

A water solubility value of 1.3 mg/l at 23°C (slightly soluble) was determined for the substance using a relevant test method. The result is considered to be reliable.

Executive summary:

Tetradecanol was determined according ASTM E 1148. The water solubility was determined to be 1.3 mg/l at 23 °C.

Reference 2

Endpoint:

water solubility

Type of information:

other: Data obtained from a handbook

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

data is taken from a reliable handbook, information about the methodology is not available

GLP compliance:

not specified

Water solubility:

0.31 mg/L

Conclusions:

A water solubility value of 0.31 mg/L was reported in a handbook which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable.

Reference 3

Endpoint:

water solubility

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Remarks:

The value was predicted using a multiple partitioning model, supported by additional validation.

Principles of method if other than guideline:

Method: other: (calculated) partition model

GLP compliance:

no

Water solubility:

0.2 mg/L

Temp.:

25 °C

The water solubility is estimated to be 0.202 mg/l at a loading rate of 1000 mg/l.

Conclusions:

A water solubility value of 0.2 mg/L was obtained at 25°C using an accepted calculation method. The result is considered to be reliable.

Reference 4

Endpoint:

water solubility

Type of information:

other: Data obtained from a secondary source

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

GLP compliance:

not specified

Water solubility:

0.31 mg/L

Temp.:

25 °C

Conclusions:

A water solubility value of 0.31 mg/L was reported at 25°C in a secondary source to which reliability could not be assigned.

Reference 5

Endpoint:

water solubility

Type of information:

other: Data obtained from a collection of reliable data

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

data is taken from a secondary source, information about the methodology is not available

GLP compliance:

not specified

Water solubility:

0.191 mg/L

Temp.:

25

Conclusions:

A water solubility value of 0.191 mg/L was reported at 25°C in a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable.

Reference 6

Endpoint:

water solubility

Type of information:

other: Data obtained from a collection of reliable data

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

GLP compliance:

not specified

Water solubility:

0.35 mg/L

Temp.:

25 °C

Conclusions:

A water solubility value of 0.35 mg/L was reported at 25°C in a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable. The result is considered to be reliable.

Description of key information

The water solubility of a commercial sample of tetradecan-1-ol is 1.3 mg/L at 23°C and pH 5.5.

Key value for chemical safety assessment

Water solubility:

1.3 mg/L

at the temperature of:

23 °C

Additional information

A water solubility value of 1.3 mg/L at 23°C and pH 5.5 was determined with the use of a flask method in accordance with ASTM E 1148. The result is considered to be reliable.

It is supported by a value of 0.191 mg/L at 25°C, taken from a reliable and definitive reference source for solubility data (Yalkowsky and He, 2003), and consistent results from other reference sources. These results are supported by a predicted water solubility value of 0.2 mg/l at 25°C which was obtained for the substance using a validated QSAR estimation method

The value taken from literature for pure alcohol (0.191 mg/l) is used in exposure modelling.

All the available results indicate that tetradecan-1-ol is slightly soluble in water.

Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:

As chain length increases, water solubility decreases, because the free energy required for a molecule to dissolve becomes less favourable for larger molecules.

Reference:

Yalkowsky,FH & He,Y. 2003. Handbook of Aqueous Solubility Data. CRC Press, Boca Raton, FL (ISBN 0-8493-1532-8)