Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information


HFC-125 is a stable molecule in water. Abiotic hydrolysis or phototransformation in water are not considered significant degradation pathways, due to the absence of hydrolysable groups and to the very high volatility of the molecule.

In the atmosphere, HFC-125 is subject to hydroxyl radical-mediated photodegradation in the troposphere, resulting in a calculated global atmospheric lifetime of 29 years.

Due to the absence of direct or indirect exposure to these compartments, the stability of HFC-125 in soil and sediment is to be considered as not relevant.


In view of the low octanol-water partition coefficient (Log Kow = 1.48), HFC-125 is not expected to bioaccumulate in the environment.

Environmental distribution

HFC-125 is released only in the atmosphere during its manufacture and use.

Due to the high Henry's Law Constant and to the predicted low adsorption potential, HFC-125 is expected to distribute mainly in the atmospheric compartment following its emission into the environment.

The environmental distribution of HFC-125 was estimated be means of the Fugacity Model Level III (2002), under the assumption that 100% release occurs in air. The Level III model’s results indicated that HFC-125 would partition mainly into the air compartment (~100%) and less than 0.001% and 0.004% in water and soil compartments, respectively.