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EC number: 206-557-8 | CAS number: 354-33-6
The aquatic PNECs were estimated by considering the lowest value obtained for structural analogues (LC50 > 100 mg/l for HFC 245fa in fish) and dividing it for the default assessment factors of 1000 for freshwater and 100 for intermittent release. As the POD is not indicative of a real LC50, derived PNECs can be considered as very conservative values.
Sediment toxicity: PNEC was estimated via the Equilibrium partitioning method (Guidance IR&CSA, R.10). The calculated Koc of 20 L/Kg was used for the estimation of the sediment-water partition coefficient Kp-sed in the equation:
Kp-sed= 0.05 * Koc = 1 L/Kg
Ksed-water was calculated in the equation:
Ksed-water = Fwater-sed + F soil-sed * (Kp-sed*2.5) = 0.8 + 0.2 * (3.05*2.5) = 1.3
and used for the PNEC estimation in the equation:
PNECsed = (Ksed-water/1.15) * PNECwater = 0.11 mg/kg w.wt. for fresh water. This PNEC can be converted to the values for dry weight sediment, by dividing for the fraction of solid in the sediments (0.2), to give the reported PNECs.
STP: No emission in STP is expected. PNEC derivation is not necessary for this compartment.
Terrestrial toxicity: No direct or indirect exposure to HFC 125 is expected for terrestrial organisms.
No PNEC derivation is necessary.
Oral (secondary poisoning): due to the very low bioaccumulation potential of HFC 125, no secondary poisoning is to be expected. PNEC derivation is not necessary.
No data are available for HFC 125. However, the comparison with other structurally related HFCs showed that no aquatic acute ecotoxicity is to be expected at concentrations ≤ 100 mg/l. Besides, due to the environmental behaviour of those substances, a very low partitioning into the aquatic environment is predictable. Based on all available data on structural analogues for daphnids, fish and algae, HFC 125 is not classifiable as hazardous to the aquatic environment. As HFC 125 does not contain Chlorine or Bromine, it is not classifiable as dangerous for the ozone layer. In conclusion, no classification for environmental endpoints is deemed necessary for HFC 125 under Directive 67/548/EEC and Regulation (EC) No. 1272/2008.
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