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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validity criteria of the test was not fulfilled because only nominal concentrations were used and no test substance was not analysed.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyltrimethylammonium chloride
EC Number:
221-221-0
EC Name:
2,3-epoxypropyltrimethylammonium chloride
Cas Number:
3033-77-0
Molecular formula:
C6H14NO.Cl
IUPAC Name:
N,N,N-trimethyl(oxiran-2-yl)methanaminium chloride
Details on test material:
2,3-Epoxypropyltrimethylammonium chloride, 72.5 %, water 19.30 %, 3-Chloro-2-hydroxypropyltrimethylammoniumchloride, 3 %,
2,3-Dihydroxypropyltrimethylammoniumchloride, 2.9 %, Total active matter as epoxyde 74.87 %
Purity 92.77 %

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
725 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1 992 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
24 h
Dose descriptor:
LC50
Effect conc.:
2 532 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
2 233 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
72 h
Dose descriptor:
LC50
Effect conc.:
2 114 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
> 2 320 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
A 96 h LC50 value of 1992 mg/L has been determined for the effects of EPTAC on the mortality of the freshwater fish Brachydanio rerio (new name: Danio rerio). The study has been selected as key as it is the lowest reliable study available, however the report was not available for review.