Registration Dossier
Registration Dossier
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EC number: 203-366-1 | CAS number: 106-14-9
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature source (documentation insufficient for assessment).
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Ricinus Communis (Castor) Seed Oil, Hydrogenated Castor Oil, Glyceryl Ricinoleate, Glyceryl Ricinoleate SE, Ricinoleic Acid, Potassium Ricinoleate, Sodium Ricinoleate, Zinc Ricinoleate, Cetyl Ricinoleate, Ethyl Ric
- Author:
- Cosmetic Ingredient Review (CIR) Panel
- Year:
- 2 007
- Bibliographic source:
- Int. J. Toxicol. 26(3):31–77
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- A patch test, with 30% hydrogenated castor oil, was conducted on one to twenty patients (age not stated) either suffering from or suspected of suffering from contact allergy to cosmetic products, to evaluate if the test material is sensitizing to human.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Castor oil, hydrogenated
- EC Number:
- 232-292-2
- EC Name:
- Castor oil, hydrogenated
- Cas Number:
- 8001-78-3
- IUPAC Name:
- 8001-78-3
- Details on test material:
- - Name of test material (as cited in study report): Hydrogenated castor oil
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- No data
- Clinical history:
- - History of allergy or casuistics for study subject or populations: either suffering from or suspected of suffering from contact allergy to cosmetic products
- Controls:
- Not applicable
- Route of administration:
- dermal
- Details on study design:
- ADMINISTRATION
- Vehicle / solvent: petrolatum
- Concentrations: 30%
Results and discussion
- Results of examinations:
- RESULT OF CASE REPORT: no reactions to 30% hydrogenated castor oil
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- The patch test result indicated that 30% test substance did not induce contact allergy in human.
- Executive summary:
A patch test, with 30% hydrogenated castor oil, was conducted on one to twenty patients (age not stated) either suffering from or suspected of suffering from contact allergy to cosmetic products, to evaluate if the test material is sensitizing to human.
The patch test result indicated that 30% test substance does not induce contact allergy in human.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
