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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Toxicological information


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Administrative data

Description of key information

Magnesium carbonate is not expected to pose a risk of carcinogenicity.

Key value for chemical safety assessment

Justification for classification or non-classification

No carcinogenicity classification is warranted for magnesium carbonate according to either the DSD or CLP based on evidence from genotoxicity, repeat dose studies and long term human studies.

Additional information

There are no lifetime animal studies available on magnesium carbonate in order to directly investigate its possible carcinogenic activity. Genotoxicity and repeat-dose toxicity studies on magnesium chloride are available and have been read across to magnesium carbonate. No evidence of mutagenic potential was seen in the genotoxicity studies with magnesium chloride and repeat dose studies showed no evidence of hyperplasia or pre-neoplastic lesions. Furthermore, the long term human data do not provide any indications of carcinogenicity.

Moreover, magnesium is essential for life and is ubiquitous in the natural environment. Humans are widely exposed to naturally occurring magnesium carbonate and chloride, e.g. via drinking water and food on a day to day basis. Ingested magnesium, carbonate and chloride ions are actively regulated by the body and are therefore not considered to be systemically toxic in standard test systems.