Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

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Additional information

Inhalation exposure of humans at 695 mg/m3 for 4 hours showed increased CO-Hb levels and decreased tracking performance, as well as a decline in response time in the visual-peripheral component of dual-tasking. Based on human data dichloromethane might be irritating to the respiratory tract at high concentrations. There is no direct indication that dichloromethane is a sensitizer of any practical significance in humans. Limited epidemiological studies suggest long-term occupational exposures in the range of 174-1677 mg/m3 may not produce overt signs of neuro- or hepatotoxicity. No consistent relationships between dichloromethane and cancer at any particular site have been reported in studies of workers exposed to dichloromethane. There is no strong epidemiological evidence to suggest that dichloromethane is harmful to fertility or during pregnancy.