Registration Dossier
Registration Dossier
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EC number: 203-492-7 | CAS number: 107-46-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Does not meet criteria of a guideline study; route of exposure not relevant
Data source
Reference
- Reference Type:
- publication
- Title:
- Biologically active|compounds of silicon.
- Author:
- Voronkov, M.G. and Lukevics, E.
- Year:
- 1 969
- Bibliographic source:
- Russian Chem Reviews 38: 975-986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexamethyldisiloxane
- EC Number:
- 203-492-7
- EC Name:
- Hexamethyldisiloxane
- Cas Number:
- 107-46-0
- Molecular formula:
- C6H18OSi2
- IUPAC Name:
- trimethyl[(trimethylsilyl)oxy]silane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No further details available
Applicant's summary and conclusion
- Conclusions:
- In an acute intraperitoneal study (reliability score 3) no deaths occurred after injection of 4500 mg/kg bw HMDS to mice (no further details available).
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