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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1961
Report Date:
1961

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Internal BASF method was used, which was in large part equivalent to OECD guideline 401
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Hexandiol-1,6

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: mean 145 g (female), mean 172 g (male)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 20%
Doses:
2500, 3200, 6400 mg/kg bw
No. of animals per sex per dose:
2500 mg/kg bw: 3 male, 2 female
3200 mg/kg bw: 6 male, 4 female
6400 mg/kg bw: 2 male, 3 female
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days (2500 and 6400 mg/kg bw), 14 days (3200 mg/kg bw)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mortality

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 3 000 mg/kg bw
Mortality:
2500 mg/kg bw: 0/5 within 7 days
3200 mg/kg bw: 7/10 within 24 h
6400 mg/kg bw: 4/5 within 24 h; 5/5 within 7 days
Clinical signs:
2500 mg/kg bw: slight staggering within 24 h
3200 mg/kg bw: apathy within 1 h; lateral position, narcotic state, atonia, constant urination within 3 h; surviving animals showed no symptoms
6400 mg/kg bw: slight apathy and slight atonia within 1 h; lateral position, increas urination, within 3 h; 4/5 deaths within 3 - 6 h; piloerection within 24 h; no symptomps within 3 days
Gross pathology:
no abnormalities found

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU