Registration Dossier
Registration Dossier
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EC number: 211-074-0 | CAS number: 629-11-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- BASF AG
- Bibliographic source:
- ECB IUCLID dataset
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- BASF AG
- Year:
- 2 000
- Bibliographic source:
- OECD SIDS
- Reference Type:
- secondary source
- Title:
- 1,6-Hexanediol
- Author:
- GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
- Year:
- 1 992
- Bibliographic source:
- BUA Report 107 (October 1992)
Materials and methods
- Principles of method if other than guideline:
- Internal BASF method was used
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Hexane-1,6-diol
- EC Number:
- 211-074-0
- EC Name:
- Hexane-1,6-diol
- Cas Number:
- 629-11-8
- Molecular formula:
- C6H14O2
- IUPAC Name:
- hexane-1,6-diol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: "Hannover"
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- TEST MATERIAL
-Concentration: 10%, 20% - Doses:
- 800, 1600, 2000, 2500, 3200, 4600 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily observations
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mortality
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 300 mg/kg bw
- Mortality:
- 800 mg/kg bw: 1/5 within 7 days (killed by cohoused animals)
1600 mg/kg bw: 0/5
2000 mg/kg bw: 0/5
2500 mg/kg bw. 3/5 within 24 h; 4/5 within 7 days
3200 mg/kg bw: 5/5 within 24 h
6400 mg/kg bw: 5/5 within 24 h - Clinical signs:
- 800 mg/kg bw: staggering and slight hyperactivity
1600 mg/kg bw: hyperactivity; lateral position, accelerated respiration, atonia, after 4 h without symptomps
2000 mg/kg bw: staggering, atonia, lateral position, intermittent respiration, narcotic state, after 3 days without symptoms
2500 mg/kg bw: hyperactivity, lateral positionor or back posture, atonia, intermittent respiration, 2 deaths within 4 h
3200 mg/kg bw: hyperactivity, lateral positionor or back posture, atonia, intermittent respiration,3 deaths within 5 h, white-colored eyes after exitus
6400 mg/kg bw: intermittent respiration, lateral position or back posture, atonia, narcotic state, deaths within 1 - 4 h; white-colored eyes after exitus - Gross pathology:
- no abnormalities found
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
