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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1961
Report date:
1961

Materials and methods

Principles of method if other than guideline:
Internal BASF method was used
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexane-1,6-diol
EC Number:
211-074-0
EC Name:
Hexane-1,6-diol
Cas Number:
629-11-8
Molecular formula:
C6H14O2
IUPAC Name:
hexane-1,6-diol

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.43, 2.37 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact
Vehicle:
water
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): ca. 1 ml
- Concentration (if solution): 80%
Duration of treatment / exposure:
1, 5, 15 min, 20 h
Observation period:
3 d
Number of animals:
2
Details on study design:
TEST SITE
- Area of exposure: back of animal; 2.5 x 2.5 cm


REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol and Lutrol/water (1:1)
- Time after start of exposure: 20 h


SCORING SYSTEM:
Gradings for erythema and edema scoring could be converted to numerical grading system acc. to Draize:
0 = no symptom - questionable
1 = slight
2 = marked
>= 3 = severe

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 - 72 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable
Remarks on result:
other: for 1min to 20 h applictions
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 - 72 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable
Remarks on result:
other: for 1min to 20 h applictions

Any other information on results incl. tables

Results:

Exposure period: 1 min Exposure period: 5 min Exposure period: 15 min Exposure period: 20 h
Readings Animal Erythema Edema Additional findings Erythema Edema Additional findings Erythema Edema Additional findings Erythema Edema Additional findings
1h 1 0 0   0 0   0 0   0 0  
2 0 0   0 0   0 0   0 0
24 h 1 0 0   0 0   0 0   0 0  
2 0 0   0 0   0 0   0 0  
48 h 1 0 0   0 0   0 0   0 0  
2 0 0   0 0   0 0   0 0  
72 h 1 0 0   0 0   0 0   0 0  
2 0 0   0 0   0 0   0 0  
8 d 1 0 0   0 0   0 0   0 0  
2 0 0   0 0   0 0   0 0  
Mean 24 - 72 h 1 0 0   0 0   0 0   0 0  
2 0 0   0 0   0 0   0 0  
Mean   0 0   0 0   0 0   0 0  

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU