Registration Dossier
Registration Dossier
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EC number: 235-715-9 | CAS number: 12607-70-4
Endpoint summary
Administrative data
Description of key information
Nickel carbonate hydroxide is classified according to Annex I to Directive 67/548/EEC with T, R48/23
Key value for chemical safety assessment
Additional information
Inhalation: There is no data on repeated dose toxicity of nickel carbonate and -hydroxide. However, there is data to show that long-term inhalation of soluble as well as insoluble nickel compounds results in adverse effects on the lungs including chronic inflammation and fibrosis. Chronic lung inflammation and lung fibrosis are serious and potentially irreversible effects. Therefore, classification of nickel carbonate and -hydroxide as T; R48/23 is considered appropriate, based on data from other nickel compounds, supported by the data for nickel carbonate showing effects on macrophages in rabbits (EU C&L Dossier and OECD SIDS Draft 2007).
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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