Registration Dossier
Registration Dossier
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EC number: 260-906-9 | CAS number: 57693-14-8
Endpoint summary
Administrative data
Description of key information
After oral as well as dermal acute exposure the lethal doses were above 2000 mg/kg bw in all studies. Minor adverse effects occurred only after high oral doses. No inhalation toxicity study is available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The result of the key study is supported by a number of older studies all confirming the low toxic potential of the test material.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity: LD50 was at least 2000 mg/kg bw, some studies even indicate a value of >10000 mg/kg bw. The observed effects were limited to diarrhea and discolored urine in some animals. Overall all studies support the notion that the test material is absorbed after oral application, but does not have a significant toxic potential in rats after acute exposure.
Acute inhalation toxicity: the inhalation route is not deemed a significant exposure route as the test material is a non volatile solid that is used either in solution or in non dusty preparations.
Acute dermal toxicity: dermal exposure did not cause any adverse effects after acute exposure of rats.
Justification for classification or non-classification
As the mean lethal doses are above the threshold for classification within the CLP Regulation (EC 1272/2008), i.e. 2000 mg/kg bw after oral as well as dermal exposure, the test material is not classified for acute systemic toxicity.
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