Registration Dossier
Registration Dossier
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EC number: 233-118-8 | CAS number: 10039-54-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of oxygen consumption by activated sludge was investigated in a study conducted according to OECD Guideline 209 and OECD Principles of Good Laboratory Practice (BASF AG 2007). Activated sludge was obtained from a municipal wastewater treatment plant, test concentrations ranged from 0.05 to 504 mg/L (nominal). After 180 minutes incubation at 20 ± 2 °C the respiration rates were recorded. An EC10 of 0.7 mg/l was determined. At 50.4 mg/L 56% inihibition was observed (EC 50), at 504 mg/L 78% inhibition.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 0.7 mg/L
Additional information
Other findings (e.g. Amarger & Alexander 1968), indicate an inhibition of microbial activity due to high concentrations of hydroxylamine. However, since hydroxylamine is an intermediate in the nitrification process, in lower concentrations hydroxylamine is expected to be degraded biologically to nitrite (e.g. Jetten et. al. 1997).
Taking these findings together with the data concerning transformation of bis(hydroxylammonium) sulphate, it can be assumed that the toxicity to microorganisms is associated with high concentrations of the hydroxyl-ammonium ion or hydroxylamine. In sewage treatment plants pH is buffered to pH 8 where the hydroxyl-ammonium ion is present only in very low concentrations. In addition to that, hydroxylamine (free base) is expected to decompose rapidly due to abiotic processes. The remaining concentration is not expected to inhibit microbial activity. Hence it can be assumed that additional biological degradation occurs in the waste water treatment plant." (EU-RAR Draft 14. May 2008)
References:
Amarger,N.,Alexander,M.1968.Nitrite formation from hydroxylamine and oximes by Pseudomonas aeruginosa. Journal of Bacteriology 95:1651–1657.
Jetten M. S. M. et al, 1997, Water Research, Volume 31, Issue 8: 1955-1962
ECB (2008). EU-RAR Draft, Bis-(hydroxylammonium) sulphate, CAS: 10039 -54 -0,14. May 2008
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