Registration Dossier
Registration Dossier
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EC number: 203-808-3 | CAS number: 110-85-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: STudy perfomred according to guideline and under GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Protocol EU Off. Journal L133, 30 , pp118-122
- Deviations:
- yes
- Remarks:
- Reference compound
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- Stock solution 25.2 g/l was titrated to neutral pH
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 30 min
- Test temperature:
- 20°C
- pH:
- 7.4 - 7.8
- Nominal and measured concentrations:
- 0, 20, 60, 180, 540, 1620 mg/l nominal
- Reference substance (positive control):
- yes
- Remarks:
- 2, 4, 5-trichlorophenol
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 1 600 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 30 min
- Dose descriptor:
- NOEC
- Effect conc.:
- 540 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- EC50 is within prescribed range 5- 30 mg/l
- Validity criteria fulfilled:
- yes
- Conclusions:
- Activated sludge respiration inhibition NOEC (30 min) is 540 mg/l.
- Executive summary:
In an Activated sludge respiration inibition test, according to EU guideline 30 min NOEC for respiration inhibition was 540 mg/l. The tested concentrations were 0, 20, 60, 180, 540, 1620 mg/l nominal. EC20 was >1600 mg/l
Reference
Description of key information
No EC50 value could be determined in an activated sludge respiration inhibition test. The EC20 was 1620 mg/L and the NOEC 540 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 540 mg/L
Additional information
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