Registration Dossier

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Piperazine is readily absorbed from the gastrointestinal tract in studies with pigs.The major part of the compound is excreted as unchanged piperazine during the first 48 hours. An oral absorption of 100% can be assumed. No data on dermal or respiratory uptake have been located. Default absorption values of 100% are assumed for dermal and inhalatory exposure.

The principal route of excretion of piperazine and its metabolites is via urine, with a minor fraction recovered from faeces (16%). About one fourth of a single administered oral dose is retained in the tissues after 7 days, some of which seems to consist of unidentified conversion products.