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EC number: 204-469-4 | CAS number: 121-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Pseudokirchneriella subcapitata, OECD Guideline 201: ErC50(72h): 8.0 mg/L, NOECr(72h): 1.1 mg/L; based on AUC: EC50(72h): 6.8 mg/L, NOEC(72h): 1.8 mg/L (Ministry of the Environment in Japan, 1999)
RA approach (tripropylamine, CAS 102-69-2), Desmodesmus subspicatus, DIN 38423 L9: EC50(96h): 24.82 mg/L (growth rate), EC50(96h): 15.14 mg/L (biomass) (BASF AG, 1989)
Effect concentration: 1 mg/L (Bringmann and Kuhn, 1959).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 8 mg/L
- EC10 or NOEC for freshwater algae:
- 1.1 mg/L
Additional information
The Ministry of the Environment in Japan (1999d) conducted an ecotoxicity experiment to investigate the acute toxicity towards the freshwater algae Pseudokirchneriella subcapitata. The experimental conditions were in accordance with OECD Guideline 201. Based on the growth rate, the ErC50(72h) was determined as 8.0 mg/L while the NOEC(72h) amounts to 1.1 mg/L. Based on the Area Under the Curve (AUC), the EC50(72h) is reported as 6.8 mg/L while the NOEC(72h) amounts to 1.8 mg/L.
As supporting information, a read-across approach is intended to tripropylamine (CAS 102-69-2) which is based on the structural analogy to the test substance triethylamine (CAS 121-44-8). The toxicity of tripropylamine towards Desmodesmus subspicatus was investigated according to German industrial standard test guideline DIN 38423, part L9 (BASF AG, 1989). No GLP compliance is reported. Following a preliminary range-finding test, the test organisms were exposed to nominal concentrations of the test substance of 0, 5, 10, 25, 50, 100 and 250 mg/L as well as 250 mg/L neutralised test solution. The test duration was 96 hours at a temperature of 21.8 °C. EC50 values based on growth rate as well as on biomass were reported as 24.82 mg/L and 15.14 mg/L, respectively. The toxic effects of the substance are probably due to an increase in pH at high concentrations of the test substance. The read-across is based upon the structural analogy of both chemicals.
Another supporting study was performed by Bringmann and Kuhn (1959). Scenedesmus quadricauda was exposed to triethylamine in a static freshwater test for 96 hours. As basis of effects, the cell number population and the abundance in the population were taken into consideration. As final result, an effect concentration of 1 mg/L is reported which is based on cell number population. Further specifications of the effective concentration are not provided in the publication.
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