Sodium acrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1961

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1961

Report date:

1961

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

- Principle of test: BASF test using an internal method, as the study was conducted before the implementation of GLP and OECD guideline 403 (1981). This test (also called inhalation hazard test) was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (20 °C and 1025.2 hPa).
- Short description of test conditions:Several groups of 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during the exposure, and the amount of air used during the exposure.
- Parameters analysed / observed: Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals. The clinical signs and findings were reported in summarized form. The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with volatile components of the test substance.

GLP compliance:

no

Test type:

other:

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Sodium acrylate

EC Number:

231-209-7

EC Name:

Sodium acrylate

Cas Number:

7446-81-3

Molecular formula:

C3H3NaO2

IUPAC Name:

sodium acrylate

Details on test material:

- Name of test material (as cited in study report): Sodium acrylate
- Physical state: solid
- Analytical purity: no data

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: not specified
- Purity: not specified

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 135 g (mean)

ENVIRONMENTAL CONDITIONS: no details reported

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

air

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

approx. 0.025 mg/L

No. of animals per sex per dose:

6

Control animals:

no

Statistics:

no

Results and discussion

Effect levels

Sex:

male/female

Exp. duration:

8 h

Remarks on result:

not determinable

Remarks:

No dust formation was reported during generation of the test atmosphere. Due to the solid nature and low vapour pressure of the test substance, it can be expected that no test substance vapours were generated.

Mortality:

No mortalities occurred.

Clinical signs:

other: The animals did not show any clinical signs of toxicity during or after exposure.

Body weight:

Body weights increased slightly within the 7-day study period up to a mean of 142 g.

Gross pathology:

At necropsy no abnormalities were observed.

Any other information on results incl. tables

No mortalities after 8-hour exposure to an atmosphere enriched with the test substance at 20°C. No dust formation was reported during generation of the test atmosphere. Due to the solid nature and low vapour pressure of the test substance, it can be expected that no test substance vapours were generated.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met