Sodium acrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 Sep - 16 Oct 1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

BASF Test
- Principle of test: In principle, the methods described in OECD Guideline 401 were used.
- Short description of test conditions: 2 and 5 rats per dose respectively were treated by gavage with preparations of the test substance in 0.5 % CMC.
- Parameters analysed / observed: Group-wise documentation of clinical signs was performed over the 7-day (2000 and 4000 mg/kg bw) and 14-day study period (5000 mg/kg bw), respectively. Body weight was determined before the start of the study, as it was needed for determination of dose, and at test termination. The clinical signs and findings were reported in summary form.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium acrylate

EC Number:

231-209-7

EC Name:

Sodium acrylate

Cas Number:

7446-81-3

Molecular formula:

C3H3NaO2

IUPAC Name:

sodium acrylate

Details on test material:

- Name of test material (as cited in study report): Sodium acrylate
- Analytical purity: approx. 99 % (not stabilised)

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier): Dr. Nestler (manufacturer)
- Lot/batch number of test material: not specified
- Purity: approx. 99%

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: cool, dry, protected from light
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions (e.g. in the exposure medium) and during storage: stable for 3 month

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Mean weight at study initiation: 191 g (males); 190 g (females)


ENVIRONMENTAL CONDITIONS: no details reported

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

VEHICLE
- Concentration in vehicle: aqueous suspension in 0.5 % CMC

MAXIMUM DOSE VOLUME APPLIED: 2.0 mL/animal

Doses:

2000, 4000 and 5000 mg/kg bw

No. of animals per sex per dose:

- 2 animals per sex at 2000, and 4000 mg/kg bw
- 5 animals per sex at 5000 mg/kg bw

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days (2000 and 4000 mg/kg bw) and 14 days (5000 mg/kg bw)
- Frequency of observations and weighing: Body weight determination of groups was performed at test start and termination. Lethality and clinical signs of toxicity were observed daily with the exception of weekends and holidays.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Statistics:

no statistics were performed

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality occurred at any dose level.

Clinical signs:

other: No clinical signs of toxicity were observed at any dose level.

Gross pathology:

At necropsy of survivors, no gross-pathological abnormalities were detected.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met