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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral dose toxicity determined by the method of Smyth et al. (1962), no details on method provided.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Route of administration:
oral: unspecified
Vehicle:
water
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
9.5 mL/kg bw
95% CL:
>= 5.4 - <= 12.3
Remarks on result:
other: 475 mg/kg bw
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
7.5 mL/kg bw
95% CL:
>= 5 - <= 11
Remarks on result:
other: 375 mg/kg bw

The following table is reproduced from the publication. Only the relevant part concerning oxalic acid is reproduced.

Material studied

Single oral LD50

Male rats

Other

Oxalic acid (5%)

9.5 (5.4-12.3) [mL/kg]

7.5 (5.0-11.0) [mL/kg] (females)

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
In a single oral toxicity test with a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg (475 mg/kg bw) was determined in male rats, and an LD50 of 7.5 mL/kg (375 mg/kg bw) was determined in female rats, under the current test conditions.
Executive summary:

In this study, the single oral dose toxicity of 110 organic and inorganic compounds, including oxalic acid, was tested. For a 5% aqueous solution of oxalic acid, an LD50 of 9.5 mL/kg was determined in male rats, and an LD50 of 7.5 mL/kg was determined in female rats, under the current test conditions.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
375 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available
Quality of whole database:
Data waiving

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: authoritative database and European Agency Report.
Qualifier:
no guideline followed
Principles of method if other than guideline:
No
GLP compliance:
no
Species:
rabbit
Key result
Dose descriptor:
LD50
Effect level:
20 000 mg/kg bw
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Despite the result of the reported study, the substance is classified as harmful in contact with the skin, according to Harmonised classification - Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation)
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
20 000 mg/kg bw

Additional information

Justification for classification or non-classification