Registration Dossier
Registration Dossier
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EC number: 205-634-3 | CAS number: 144-62-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD), GLP compliance.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- COMPLIANCE WITH GOOD LABORATORY PRACTICE I the undersigned declare that the studies described in this report have been conducted under my supervision and in compliance with the following standards of Good Laboratory Practice: Organization for Economic Co-
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 162.2 mg/L
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- no
- Conclusions:
- The 48h EC50 was 162.2 mg/l
- Executive summary:
Daphnia magna were exposed to oxalic acid during 48 h according to the guideline OECD TG 202 in a GLP laboratory test. An 48 h EC50 of 136.9 mg/l was determined.
Reference
Quality criteria have been satisfied:
% of Daphnie immobilized present in control: 0
Analytical verification of the concentration of the test substance
The test substance is considered stable, because the HPLC-UV values, at the beginning and at the
end of the test, at lower and higher concentration, remain within the required range, so results are
referred to the nominal concentration.
The percentage stability for lower concentration is 99%
The percentage stability for higher concentration is 100%
The results are reported in the Appendix 5.
EC50
EC50was evaluted using EPA Probit analysis program version1.5.
On the basis of results, interpreted according with OECD guideline N° 202, the test substance
“OXALIC ACID DI-HYDRATE” has an EC50(48h) of 162.2 mg/l.
Description of key information
Daphnia magna were exposed to oxalic acid during 48 h according to the guideline OECD TG 202 in a GLP laboratory test. An 48 h EC50 of 136.9 mg/l was determined.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 162.2 mg/L
Additional information
A GLP laboratory test following OECD TG 202 guideline was conducted.
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