Registration Dossier
Registration Dossier
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EC number: 202-626-1 | CAS number: 98-00-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- no data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from publshed review; adequate for consideration as part of a weight of evidence assessment.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Criteria for a recommended standard – occupational exposure to furfuryl alcohol.
- Author:
- US National Institute for Occupational Safety & Health
- Year:
- 1 979
- Bibliographic source:
- DHEW (NIOSH) Publication 79-133
- Reference Type:
- other: primary citation; company data
- Title:
- Physiological data on furfuryl alcohol Project 1011-B, Report No 2,Chicago
- Author:
- Woods LA & Seevers MH
- Year:
- 1 954
- Bibliographic source:
- The Quaker Oats Co, Chemicals Division, 15 pp (cited in NIOSH, 1979)
Materials and methods
- Principles of method if other than guideline:
- Undiluted furfuryl alcohol was instilled, slowly into one eye of each of 4 rabbits.
- GLP compliance:
- no
Test material
- Reference substance name:
- Furfuryl alcohol
- EC Number:
- 202-626-1
- EC Name:
- Furfuryl alcohol
- Cas Number:
- 98-00-0
- Molecular formula:
- C5H6O2
- IUPAC Name:
- (furan-2-yl)methanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.05 mL or 56 mg
- Duration of treatment / exposure:
- single instillation
- Observation period (in vivo):
- 64 days
- Number of animals or in vitro replicates:
- 4
Results and discussion
In vivo
Results
- Irritation parameter:
- other: eye irritation observations
- Basis:
- other: all 4 rabbits
- Time point:
- other: up to 64 days
- Reversibility:
- fully reversible within: 40-64 days
- Remarks on result:
- other: instillation resulted in eye inflammation, viscid mucoid secretion, corneal opacity and eyelid swelling
Any other information on results incl. tables
Instillation with 0.02 mL (23 mg) produced the same but less severe effects, with recovery after 2-8 days.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- Furfuryl alcohol was irritating to rabbit eyes after instillation of 0.05 mL (56mg) and 0.02 mL (23 mg) with recovery after 40-64 days and 2-8 days respectively.
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