Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
100 mg/kg bw/day
Study duration:
subacute
Species:
rat

Additional information

The oral toxicity of tetrahydrophthalic Anhydride (THPA) over an exposure period of 4 consecutive weeks and recovery from any potential treatment-related effects over a period of 2 consecutive weeks has been investigated. Methods were in accordance with OECD/EU test guidelines. No clinical signs of toxicity were observed and no significant variations were observed in haematology and clinical chemistry parameters. The high dose of 600 mg/kg/day was considered to be the No Observed Adverse Effect Level (NOAEL) for systemic toxicity and the low dose of 100 mg/kg/day was considered to be the No Observed Adverse Effect Level (NOAEL) for local effects.

 


Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: stomach

Justification for classification or non-classification

Those effects of treatment observed following repeated administration of the substance at high doses are not of sufficient severity to justify classification