Registration Dossier
Registration Dossier
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EC number: 237-511-5 | CAS number: 13822-56-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study was not compliant with guidelines for acute inhalation toxicity. It does, however, add weight of evidence for the acute toxicity of the substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 6 animals (sex not specified) were exposed to substantially saturated vapour for 6 hours.
- GLP compliance:
- no
- Test type:
- other: exposure to substantially saturated vapour
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(trimethoxysilyl)propylamine
- EC Number:
- 237-511-5
- EC Name:
- 3-(trimethoxysilyl)propylamine
- Cas Number:
- 13822-56-5
- Molecular formula:
- C6H17NO3Si
- IUPAC Name:
- 3-(trimethoxysilyl)propylamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Concentrations:
- Substantially saturated vapour
- No. of animals per sex per dose:
- 6
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: mortality
- Effect level:
- other: 0/6 deaths noted
- Exp. duration:
- 6 h
- Remarks on result:
- other: substantially saturated vapour
- Mortality:
- No deaths.
- Clinical signs:
- other: None
- Gross pathology:
- Nothing remarkable noted at necropsy.
Applicant's summary and conclusion
- Conclusions:
- In a non-standard study, exposure to substantially saturated vapour of 3-(triethoxysilyl)propylamine cause 0/6 deaths.
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