Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Effect of several resin monomers on water insoluble glucan formation by Glucosyltrans- ferase of Streptococus sobrinus.
Author:
Kawai K, Torii M, Tsuchitani Y
Year:
1989
Bibliographic source:
J. Osaka Univ. Dent. Sch. 29: 65-71

Materials and methods

Type of study / information:
Type: Plaque accumulation
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylene dimethacrylate
EC Number:
202-617-2
EC Name:
Ethylene dimethacrylate
Cas Number:
97-90-5
Molecular formula:
C10H14O4
IUPAC Name:
2-[(2-methylprop-2-enoyl)oxy]ethyl 2-methylprop-2-enoate
Test material form:
liquid

Results and discussion

Any other information on results incl. tables

EGDMA and eluate from EGDMA-based experimental composite showed a tendency of inhibiting GTase and the eluate from experimental resin decreased the production of WIG. The authors conclude that
EGDMA used as a diluent monomer inhibits the GTase activity and would therefore result in decreased adherence of S.
mutans and dental caries.

Applicant's summary and conclusion