Registration Dossier
Registration Dossier
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EC number: 202-617-2 | CAS number: 97-90-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- Screening-test. Only very short summary available. Only one dose, only one sex, only 3 animals.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 970
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
Materials and methods
- Principles of method if other than guideline:
- Screening-test
- GLP compliance:
- no
- Test type:
- other: subacute
- Limit test:
- yes
Test material
- Reference substance name:
- Ethylene dimethacrylate
- EC Number:
- 202-617-2
- EC Name:
- Ethylene dimethacrylate
- Cas Number:
- 97-90-5
- Molecular formula:
- C10H14O4
- IUPAC Name:
- 2-[(2-methylprop-2-enoyl)oxy]ethyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Duration of exposure:
- 6 - 7 h
- Remarks on duration:
- subacute study: 13 x daily; 5 days a week
- Concentrations:
- 1 mg/L (120 ppm)
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no, Animals were killed at the end of exposure period.
Three rats were exposed to air which had been bubbeled through the test substance. From the measured loss in weight of the liquid the atmospheric concentration was calculated.
Results and discussion
- Preliminary study:
- The animals became somewhat lethargic during the exposures but no definite symptomes developed. Normal weight gain. The post mortem examination showed some discolouration of the lungs. A histological examination of the lungs showed some thickening of the alveolar walls with a lymphocytic reaction around the bronchioles. The other major organs showed no signs of patological changes.
Effect levels
- Sex:
- female
- Dose descriptor:
- LCLo
- Effect level:
- > 1 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: 1 mg/L corresponds to 120 ppm; exposure 6 or 7 hrs/d; screening test performed for 13 days
- Mortality:
- No mortality.
- Body weight:
- Normal weight gain.
- Gross pathology:
- The other major organs showed no signs of patological changes.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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