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REACH

Pyrithione zinc

EC number: 236-671-3 | CAS number: 13463-41-7

Life Cycle description
Uses advised against

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Fresh water fish

Effect concentration:: 0.003 mg/L

Marine water fish

Effect concentration:: 0.4 mg/L

Additional information

The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under RegulationEC 1907/2006.

The acute studies on fish indicate that ZPT is toxic to fish. The LC₅₀values range from 0.0026 to 0.4 mg ZPT/L withPimephales promelas(Fathead minnow) being the most sensitive species (seeTable40).

Acute exposure of fish (Pimephalespromelas) to ZPT resulted in an NOEC value of 0.0011 mg ZPT/L.

Further, acute toxicity studies in fish for the major metabolites (seeTable41andTable42) indicate that the most toxic substance is Pyrithione disulphide with a NOEC of 0.03-1.1 mg/L, again to the freshwater species Pimephales promelas (Fathead Minnow), but that this is some 30 times less toxic than the parent compound Zinc Pyrithione. However, Pyrithione disulphide is very short lived in the environment and the most relevant degradant of ZPT is Pyridine sulphonic acid (PSA).

Table35:Acute toxicity of ZPT to fish

Guideline / Test method	Species	End-point / Type of test	Exposure		Results [mg/L]			Remarks	Reference
Guideline / Test method	Species	End-point / Type of test	design	duration	NOEC	LC₅₀	LC₁₀₀	Remarks	Reference
US EPA- 72-1	Freshwater Fathead Minnow Pimephales promelas	Mortality	Flow-through	96 hours	0.0011	0.0026	>0.0079	Key study NOEC assigned to concentration that allowed at least 90% survival and did not cause sub lethal effects	Boeri RL, Magazu JP, Ward TJ (1994) Unpublished study
US EPA- 72-3 (b)	Marine Sheepshead Minnow Cyprinodon variegates	Mortality	Semi-static	96 hours	0.20	0.40	0.59	-	Boeri RL, Magazu JP, Ward TJ (1994) Unpublished study
US EPA- 72-1	Freshwater Rainbow trout Oncorhyncus mykiss	Mortality	Flow-through	96 hours	0.0016	0.0032	0.0087	-	Boeri RL, Magazu JP, Ward TJ (1994) Unpublished study
US EPA -540/9-85-006	Freshwater Rainbow trout Oncorhyncus mykiss	Mortality	Flow-through	96 hours	<0.018	0.150	0.320	-	Croudace CP, Caunter JE, Eales GJ (1996). Unpublished study

Table36:Acute toxicity ofPyridine-N-oxide-2-sulfonic acidto fish

Guideline / Test method	Species	End-point / Type of test	Exposure		Results [mg/L]			Remarks	Reference
Guideline / Test method	Species	End-point / Type of test	design	duration	NOEC	LC₅₀	LC₁₀₀	Remarks	Reference
US EPA- 72-1	Freshwater Fathead Minnow Pimephales promelas	Mortality	Flow-through	96 hours	48.7	58.8	-	Key study	Ward TJ, Kowalski PL, Boeri RL (1994) Unpublished study
US EPA- 72-1	Freshwater Rainbow trout Oncorhyncus mykiss	Mortality	Flow-through	96 hours	73.6	92.3	-	-	Ward TJ, Kowalski PL, Boeri RL (1994) Unpublished study
US EPA- 72-3 (b)	Marine Sheepshead Minnow Cyprinodon variegatus	Mortality	Flow-through	96 hours	137	>137	-	-	Boeri RL, Kowalski PL, Ward TJ (1994) Unpublished study

Table37:Acute toxicity of Pyridine sulphonic acid to fish

Guideline / Test method	Species	End-point / Type of test	Exposure		Results [mg/L]			Remarks	Reference
Guideline / Test method	Species	End-point / Type of test	design	duration	NOEC	LC₅₀	LC₁₀₀	Remarks	Reference
US EPA- 72-1	Freshwater Fathead Minnow Pimephales promelas	Mortality	Flow-through	96 hours	55.2	68.5	-	-	Boeri RL, Kowalski PL, Ward TJ (1994) Unublished study
US EPA- 72-1	Freshwater Rainbow trout Oncorhyncus mykiss	Mortality	Flow-through	96 hours	46.9	57.1	-	-	Ward TJ, Kowalski PL, Boeri RL (1993) Unpublished study
US EPA- 72-3 (b)	Marine Sheepshead Minnow Cyprinodon variegatus	Mortality	Flow-through	96 hours	127	>127	-	-	Boeri RL, Kowalski PL, Ward TJ (1994) Unpublished study

Table38:Acute toxicity of 2,2’-(pyridyl-N-oxide) disulphide to fish

Guideline / Test method	Species	End-point / Type of test	Exposure		Results [mg/L]			Remarks	Reference
Guideline / Test method	Species	End-point / Type of test	design	duration	NOEC	LC₅₀	LC₁₀₀	Remarks	Reference
US EPA- 72-1	Freshwater Fathead Minnow Pimephales promelas	Mortality	Flow-through	96 hours	0.011	0.030	-	-	Ward TJ, Magazu JP, Boeri RL (1995) Unpublished study
US EPA- 72-1	Freshwater Rainbow trout Oncorhyncus mykiss	Mortality	Flow-through	96 hours	0.018	0.054	-	-	Ward TJ, Magazu JP, Boeri RL (1995) Unpublished study
US EPA- 72-3 (b)	Marine Sheepshead Minnow Cyprinodon variegatus	Mortality	Flow-through	96 hours	<0.52	1.1	-	-	Ward TJ, Magazu JP, Boeri RL (1995) Unpublished study

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