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EC number: 701-025-6 | CAS number: 26038-87-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 September 2017 - 10 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- liquid chromatography
- other: ICP-MS
- Type:
- log Pow
- Partition coefficient:
- -1.9
- Temp.:
- 19.7 °C
- pH:
- >= 8.3 - <= 8.6
- Remarks on result:
- other: Partition coefficient of polyborate moiety
- Remarks:
- The pH measured for the samples is in the environmental range (5-9) and therefore this was considered to have no impact in the study and the results.
- Type:
- log Pow
- Partition coefficient:
- -1.1
- Temp.:
- 19.7 °C
- pH:
- >= 8.3 - <= 8.6
- Remarks on result:
- other: Partition coefficient for organic moiety
- Remarks:
- The pH measured for the samples is in the environmental range (5-9) and therefore this was considered to have no impact in the study and the results.
- Details on results:
- The log Pow values were within the acceptable range of ± 0.3 log units.
- Conclusions:
- The partition coefficient (log Pow) of Reaction products of monoenthanolamine and boric acid (1:1) in an OECD 107 study under GLP conditions was the following:
- at 19.7°C, pH 8.3-8.6, for the polyborate moiety is -1.9.
- at 19.7°C, pH 8.3-8.6, for the organic moiety is -1.1.
The determined log Pow values were within the acceptable range of ± 0.3 log units. - Executive summary:
The n-octanal/water partition coefficient of the test item was determined according to OECD guideline 107 and EC method A.8. The analytical methods were validated following SANCO/3029/99 rev. 4. The determined partition coefficient (log Pow) at 19.7°C, pH 8.3 -8.6, for the polyborate moiety is -1.9. The determined partition coefficient (log Pow) at 19.7°C, pH 8.3 -8.6, for the organic moiety is -1.1.
Reference
Partition coefficient for polyborate moiety:
Ratio |
Analyzed concentration |
Pow |
log Pow |
pH |
||
n-octanol |
water |
individual |
mean |
|||
1:1 |
0.301 |
3.49 |
8.6 x 10-2 |
8.8 x 10-2 |
-1.1 |
9.2 |
|
0.301 |
3.27 |
9.1 x 10-2 |
|
-1.0 |
9.2 |
1:2 |
0.261 |
2.64 |
9.9 x 10-2 |
9.7 x 10-2 |
-1.0 |
9.1 |
|
0.251 |
2.65 |
9.6 x 10-2 |
|
-1.0 |
9.1 |
2:1 |
0.341 |
4.48 |
7.7 x 10-2 |
7.6 x 10-2 |
-1.1 |
9.3 |
|
0.351 |
4.67 |
7.5 x 10-2 |
|
-1.1 |
9.3 |
Mean |
8.7 x 10-2 |
|
-1.1 |
|
||
Standard deviation |
9.8 x 10-3 |
|
|
|
||
1 Estimated value, calculated by extrapolation of the calibration curve.
Partition coefficient for organic moiety:
Ratio |
Analyzed concentration |
Pow |
log Pow |
pH |
||
n-octanol |
water |
individual |
mean |
|||
1:1 |
0.0428 |
3.40 |
1.3 x 10-2 |
1.2 x 10-2 |
-1.9 |
9.2 |
|
0.0420 |
3.39 |
1.2 x 10-2 |
|
-1.9 |
9.2 |
1:2 |
0.0270 |
2.56 |
1.1 x 10-2 |
1.0 x 10-2 |
-2.0 |
9.1 |
|
0.0264 |
2.60 |
1.0 x 10-2 |
|
-2.0 |
9.1 |
2:1 |
0.0750 |
4.77 |
1.6 x 10-2 |
1.6 x 10-2 |
-1.8 |
9.3 |
|
0.0755 |
4.89 |
1.5 x 10-2 |
|
-1.8 |
9.3 |
Mean |
1.3 x 10-2 |
|
-1.9 |
|
||
Standard deviation |
2.3 x 10-3 |
|
|
|
||
Description of key information
The partition coefficient (log Pow) of Reaction products of monoenthanolamine and boric acid (1:1) in an OECD 107 study under GLP conditions was the following:
- at 19.7°C, pH 8.3-8.6, for the polyborate moiety is -1.9.
- at 19.7°C, pH 8.3-8.6, for the organic moiety is -1.1.
The determined log Pow values were within the acceptable range of ± 0.3 log units.
Key value for chemical safety assessment
Additional information
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