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EC number: 205-489-6 | CAS number: 141-57-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Gene mutation (Bacterial reverse mutation assay / Ames test): negative
with and without activation in all strains tested (OECD TG 471)
(Laboratory of Pharmacology and Toxicology, 2002)
Cytogenicity in mammalian cells: read-across from analogous substance
trichloro(methyl)silane (CAS 75-79-6): negative in L5178Y mouse lymphoma
cells with and without activation (similar to OECD TG 473) (Litton
Bionetics 1978)
Mutagenicity in mammalian cells: read-across from analogous substance
trichloro(methyl)silane (CAS 75-79-6): negative in L5178Y mouse lymphoma
cells (similar to OECD TG 476) (Litton Bionetics 1978)
The selected key study for bacterial mutagenicity was the more reliable of the two studies available. It was conducted according to an appropriate OECD guideline and under GLP. The mammalian studies are the more reliable of the available studies for the surrogate substance. They were conducted according to protocols that are similar to appropriate OECD guidelines. They were not conducted under GLP.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-03-04 to 2002-09-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor induced rat liver S9
- Test concentrations with justification for top dose:
- 31.6-3160 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
- Justification for choice of solvent/vehicle: Solvent is not harmful to bacteria - Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- Remarks:
- TA 1535, TA 100 (without activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 2-nitrofluorene
- Remarks:
- TA 98 (without activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- methylmethanesulfonate
- Remarks:
- TA 102 (without activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- cyclophosphamide
- Remarks:
- TA 98, TA 102, TA 1537 (with activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- Remarks:
- TA 1537 (without activation)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 2-anthracene amide
- Remarks:
- TA 98, TA 102, TA 1537 (with activation)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar, standard plate incorporation method, preincubation method
DURATION
- Preincubation period: 60 minutes
- Exposure duration: 48 hours
SELECTION AGENT (mutation assays): histidine deficient agar
NUMBER OF REPLICATIONS: cells were plated in triplicate; the experiment was repeated using the pre-incubation method.
DETERMINATION OF CYTOTOXICITY
- Method: other: condition of background lawn.
ACTIVATION:
Aroclor induced rat liver S9 (protein content 32.92 mg/ml, cytochrome P-450: 0.32 nmol/mg) was added to S9 mix so that the mix contained 5% S9. glucose-6-phophate and NADP were added as co-factors. 0.5 ml S9 mix was added to 2 ml of top agar to a total volume of 2.7 ml. Final concentration S9 in agar was therefore approximately 1%.
- Evaluation criteria:
- The number of revertants is significantly increased compared with the solvent control to at least 2 fold of the solvent control for TA98, TA100 and TA102 and 3 fold of the solvent control for TA 1535 and TA1537 in both independent experiments. Positive results have to be reproducible and the histidine independence of the revertants has to be confirmed by streaking random samples on histidine free agar plates.
- Statistics:
- MANN and WHITNEY and Spearman's rank correlation used.
- Key result
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- 3160 µg/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- 3160 µg/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- See tables 2-4.
COMPARISON WITH HISTORICAL CONTROL DATA: Controls were within range of historical controls
- Conclusions:
- Trichloro(propyl)silane has been tested for mutagenicity to bacteria according to OECD TG 471 and under GLP conditions in Salmonella typhimurium strains TA 98, TA 100, TA 102, TA 1535 and TA 1537. No evidence of an increase in the number of revertants was observed for the test substance when tested up to cytotoxic concentrations with and without metabolic activation in any of the test strains in either the initial plate incorporation assay or the subsequent pre-incubation test. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of test.
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- Deviations:
- yes
- Remarks:
- only 50 cells scored for aberrations, reporting has less detail than current guideline, no longer term exposure, no. of cells evaluated does not comply with current guideline
- Principles of method if other than guideline:
- Litton Bionetics standard procedure: Screening Program for the Identification of Potential Mutagens and Carcinogens. Protocol Number: DMT 100
- GLP compliance:
- no
- Type of assay:
- in vitro mammalian chromosome aberration test
- Species / strain / cell type:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with and without
- Metabolic activation system:
- mouse liver S9
- Test concentrations with justification for top dose:
- With metabolic activation: 0.02-0.32 µl/ml; without metabolic activation 0.01-0.16 µl/ml.
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: ethanol
- Justification for choice of solvent/vehicle: None given in report. - Untreated negative controls:
- yes
- Remarks:
- Medium
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- ethylmethanesulphonate
- Remarks:
- (without activation)
- Untreated negative controls:
- yes
- Remarks:
- Medium
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- N-dimethylnitrosamine
- Remarks:
- (with activation)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in medium
DURATION
- Exposure time: 4 hours
- Expression time (cells in growth medium): 20 hours
NUMBER OF REPLICATIONS: 1 plates for each test concentration
NUMBER OF CELLS EVALUATED: 50 per plate
DETERMINATION OF CYTOTOXICITY
- Method: mitotic index - Key result
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- The very slight increase in incidence of aberrations reported is not considered to be biologically relevant.
- Cytotoxicity / choice of top concentrations:
- other: >= 0.32 µl/ml (equivalent to approximately 320 µg/ml)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Conclusions:
- Trichloro(methyl)silane has been tested up to cytotoxic concentrations in a reliable assay according to a protocol that is similar to OECD TG 473. Appropriate concurrent negative and positive controls were included and the expected responses were observed. The number of cells with 2 or more aberrations increased very slightly under activation conditions, and no increase was observed at the highest dose tested. Trichloro(methyl)silane was considered by the authors of the study to have weak clastogenic activity that may be related to the cytotoxic properties of the test substance. It is concluded by the reviewer that the study does not demonstrate a biologically relevant effect.
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 476 (In Vitro Mammalian Cell Gene Mutation Test)
- Deviations:
- yes
- Remarks:
- non-activated mouse liver S9 mix used for activation
- Principles of method if other than guideline:
- Method: Litton Bionetics standard procedure: Screening Program for the Identification of Potential Mutagens and Carcinogens. Protocol Number : DMT 100
- GLP compliance:
- no
- Type of assay:
- mammalian cell gene mutation assay
- Species / strain / cell type:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with and without
- Metabolic activation system:
- Mouse liver S9
- Test concentrations with justification for top dose:
- Test 1: 0.02-0.32 µl/ml with metabolic activation, 0.01-0.16 µl/ml without metabolic activation; test 2: 0.04-0.32 µl/ml with metabolic activation, 0.04-0.32 µl/ml without metabolic activation
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: ethanol
- Justification for choice of solvent/vehicle: It is assumed by the reviewer that the solvent was chosen based on solubility properties and relative non-toxicity to bacteria - Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- ethylmethanesulphonate
- Remarks:
- (without activation)
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- N-dimethylnitrosamine
- Remarks:
- (with activation)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in medium
DURATION
- Exposure duration: 4 hours
- Expression time (cells in growth medium): 3 days
- Selection time (if incubation with a selection agent): 10 days
- Fixation time (start of exposure up to fixation or harvest of cells): 3 days 4 hours
SELECTION AGENT (mutation assays): THMG (thymidine, hypoxanthene, methoxotrexate, glycine)
NUMBER OF REPLICATIONS: 3 plates for each test concentration, assay repeated
DETERMINATION OF CYTOTOXICITY
- Method: relative total growth - Evaluation criteria:
- A compound is considered mutagenic if:
- A dose response relationship is observed over three of the four dose levels employed
- The minimum increase at the high level of the dose response curve is at least 2.5 times greater than the solvent control value
- The solvent control data are within the normal range of spontaneous background for the TK locus. - Key result
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: 0.32 µl/ml, equivalent to 320 µg/ml
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- The test substance did not induce mutation at the thymidine kinase locus with or without activation. Because there was very little toxicity observed in the non activation tests, the study was repeated. The repeat study produced greater levels of toxicity but was still negative for inducing mutations.
- Conclusions:
- Trichloro(methyl)silane was tested for mutagenicity in mammalian cells in a reliable and reproducible assay according to a protocol that is similar to OECD 476. Appropriate concurrent negative and positive controls were included and the expected responses were observed. There was no evidence of gene mutation up to cytotoxic concentrations. It is concluded that trichloro(methyl)silane is negative for the induction of mutation in mammalian cells under the conditions of the test.
Referenceopen allclose all
Table 2: Dose range-finding study Number of revertants per plate (2 plates)
|
TA100 |
||
Conc. |
Plate 1 |
Plate 2 |
Cytotoxic |
0* |
133 |
142 |
No |
0.316 |
122 |
143 |
No |
1 |
141 |
145 |
No |
3.16 |
149 |
136 |
No |
10 |
120 |
129 |
No |
31.6 |
105 |
128 |
No |
100 |
108 |
106 |
No |
316 |
103 |
111 |
No |
1000 |
134 |
133 |
No |
3160 |
104 |
112 |
Yes |
5000 |
131 |
109 |
Yes |
*solvent control with DMSO
Table 3: Experiment 1 Plate incorporation Number of revertants per plate (mean of 3 plates)
|
TA98 |
TA100 |
TA102 |
||||||
Conc. |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
0* |
28.3 |
29.3 |
No |
163 |
146.7 |
No |
288 |
286.3 |
No |
31.6 |
32 |
30.3 |
No |
142.7 |
158.7 |
No |
281 |
284.7 |
No |
100 |
28.3 |
36.7 |
No |
153 |
147.7 |
No |
290.7 |
279.3 |
No |
316 |
33.7 |
34 |
No |
147.7 |
162.7 |
No |
276.3 |
299.7 |
No |
1000 |
34 |
38 |
No |
158.3 |
146.3 |
No |
297.3 |
292.7 |
No |
3160 |
39.3 |
35 |
Yes |
164 |
156.7 |
Yes |
295.7 |
273.3 |
Yes |
Positive control |
1003 |
994 |
No |
1312.3 |
1298.7 |
No |
1313.7 |
1305 |
No |
*solvent control with DMSO
Table 3: Experiment 1 Plate incorporation Number of revertants per plate (mean of 3 plates)
|
TA1535 |
TA1537 |
||||
Conc. |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
0* |
12 |
12.7 |
No |
4.7 |
6 |
No |
31.6 |
13.7 |
11.7 |
No |
3 |
7 |
No |
100 |
11.7 |
13 |
No |
5.3 |
6.3 |
No |
316 |
12.3 |
12 |
No |
5 |
7.7 |
No |
1000 |
11 |
12 |
No |
7 |
8 |
No |
3160 |
11.7 |
11 |
Yes |
8.3 |
9 |
Yes |
Positive control |
773.3 |
780 |
No |
780 |
783.7 |
No |
*solvent control with DMSO
Table 4: Experiment 2 Preincubation Number of revertants per plate (mean of 3 plates)
|
TA98 |
TA100 |
TA102 |
||||||
Conc. |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
0* |
33 |
41.3 |
No |
117.7 |
141.7 |
No |
274.3 |
298.7 |
No |
31.6 |
45 |
43.7 |
No |
115 |
138.7 |
No |
278.3 |
272.7 |
No |
100 |
37.7 |
42 |
No |
132 |
138 |
No |
274.3 |
279.7 |
No |
316 |
36.3 |
38.7 |
No |
133.7 |
141.7 |
No |
298.7 |
265 |
No |
1000 |
34 |
44.3 |
No |
120.3 |
145 |
No |
268.3 |
278 |
No |
3160 |
0 |
0 |
yes |
0 |
0 |
yes |
0 |
0 |
yes |
Positive control |
1070 |
1059 |
No |
1199.7 |
1211 |
No |
1176.7 |
1214 |
No |
*solvent control with DMSO
Table 4: Experiment 2 Preincubation Number of revertants per plate (mean of 3 plates)
|
TA1535 |
TA1537 |
||||
Conc. |
— MA |
+ MA |
Cytotoxic |
— MA |
+ MA |
Cytotoxic |
0* |
11.7 |
11.3 |
No |
3 |
3 |
No |
31.6 |
12 |
10.7 |
No |
2.3 |
4 |
No |
100 |
11 |
11.3 |
No |
3.3 |
3 |
No |
316 |
11 |
12 |
No |
3 |
4 |
No |
1000 |
11 |
12 |
No |
3 |
3.7 |
No |
3160 |
0 |
0 |
yes |
0 |
0 |
yes |
Positive control |
646.3 |
624.3 |
No |
640.7 |
637.7 |
No |
*solvent control with DMSO
Table 2: Cytogenetic analysis (without activation)
Concentration µl/ml |
Total No. Of Cells |
Type / Frequency Aberrations per Cell (%) |
No. Of Cells with 2+ Aberrations (%) |
Mitotic Index (%) |
Negative Control |
50 |
1tb |
0 |
2.2 |
Solvent Control |
50 |
0 |
0 |
13.8 |
Positive Control |
50 |
6tb, 1f, 1t, 6qr, 5tr, 1min |
4 |
7.4 |
0.01 |
50 |
1qr |
0 |
7.4 |
0.02 |
50 |
0 |
0 |
4.6 |
0.04 |
50 |
1f |
0 |
5.2 |
0.08 |
50 |
1af, 1tb |
0 |
8.4 |
0.16 |
50 |
0 |
0 |
5.4 |
Table 3: Cytogenetic analysis (with activation)
Compound and Concentration µl/ml |
Total No. Of Cells |
Type / Frequency Aberrations per Cell (%) |
No. Of Cells with 2+ Aberrations (%) |
Mitotic Index (%) |
Negative Control |
50 |
1tb, 1> |
0 |
4 |
Solvent Control |
50 |
0 |
0 |
9 |
Positive Control |
50 |
6tb, 1f, 2t, 1tr, 1qr |
1 |
4.4 |
0.02 |
50 |
1tb |
0 |
4.4 |
0.04 |
50 |
2t, 1tr |
1 |
10.8 |
0.08 |
50 |
1tb, 3f, 1tr |
2 |
8 |
0.16 |
50 |
1tb, 1f, 1af, 1t |
1 |
7.8 |
0.32 |
50 |
0 |
0 |
10.4 |
Key to type of aberration
tb |
Chromatidbreak |
f |
Fragment |
qr |
Quadriradial |
tr |
Triradial |
min |
Minute chromosome |
af |
Acentricfragment |
t |
Translocation |
Table 2 :Results of Mammalian Mutagenicity assay (Test 1) with L5178Y/TK+/- Mouse Lymphoma cells
Concentrationµl/ml |
Mutant* Frequency |
Mutant* Frequency |
%Relative Growth. |
%Relative Growth. |
Cytotoxicity |
- MA |
+ MA |
- MA |
+ MA |
- |
|
Solvent control |
10.6 |
12.2 |
100 |
100 |
- |
Negative control |
12.2 |
10.3 |
123 |
64.1 |
- |
Positive control |
511.0 |
368.1 |
18.5 |
5.8 |
yes |
0.01 |
8.0 |
- |
134.2 |
- |
no |
0.02 |
10.8 |
23.1 |
140 |
72.5 |
no |
0.04 |
7.3 |
10.5 |
134.1 |
99.1 |
no |
0.08 |
11.3 |
14.1 |
118.1 |
101.2 |
no |
0.16 |
18.1 |
17.6 |
112.4 |
94.1 |
no |
0.32 |
- |
12.9 |
- |
45.7 |
yes |
*Per 106surviving cells
Solvent control with Ethanol
Table 3 : Results of Mammalian Mutagenicity assay (Test 2) with L5178Y/TK+/- Mouse Lymphoma cells
Concentrationµl/ml |
Mutant* Frequency |
Mutant* Frequency |
%Relative Growth. |
%Relative Growth. |
Cytotoxicity |
|
— MA |
+ MA |
— MA |
+ MA |
- |
Solvent Control |
14 |
17 |
100 |
100 |
No |
Negative Control |
25.3 |
15.8 |
83.1 |
89.2 |
No |
Positive Control |
385 |
514 |
27 |
2.8 |
No |
0.04 |
- |
15.4 |
- |
87.8 |
No |
0.08 |
26.9 |
22.1 |
65.7 |
75.6 |
No |
0.16 |
27.5 |
16.5 |
60.1 |
48 |
Yes |
0.24 |
16.5 |
- |
58.6 |
- |
No |
0.32 |
26.6 |
58 |
0.2 |
0.1 |
Yes |
*Per 106surviving cells
Solvent control with Ethanol
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
In a reliable bacterial mutagenicity study conducted according to OECD TG 471 and under GLP, no evidence of mutagenicity was observed with or without metabolic activation when trichloro(propyl)silane (CAS 141-57-1) was tested in Salmonella typhimurium strains TA 98, TA 100, TA 102, TA 1535 and TA1537 (Laboratory of Pharmacology and Toxicology, 2002). A further bacterial mutagenicity study confirmed also gave a negative result (Dow Corning Corporation, 1985).
The related substance trichloro(methyl)silane (CAS 75-79-6) has been tested up to cytotoxic concentrations in a reliable assay according to a protocol that is similar to OECD TG 473. Appropriate concurrent negative and positive controls were included and the expected responses were observed. The number of cells with 2 or more aberrations increased very slightly under activation conditions, and no increase was observed at the highest dose tested. The total number of cells with aberrations was not increased. Trichloro(methyl)silane was considered by the authors of the study to have weak clastogenic activity that may be related to the cytotoxic properties of the test substance. It is concluded by the reviewer that the study does not demonstrate a biologically relevant effect. (Litton Bionetics, 1978).
In a reliable in vitro mutagenicity study conducted according to a protocol similar to OECD TG 476, no evidence of mutagenicity was observed when trichloro(methyl)silane (CAS 75-79-6) was tested up to cytotoxic concentrations with or without metabolic activation in L5178Y mouse lymphoma cells (Litton Bionetics, 1978).
The most reliable studies were chosen as key. Where there was more than one reliable study, the most recent was selected. The results of all the studies are in agreement. In vivo testing is not required as no evidence for genetic toxicity was found in the in vitro studies.
Justification for classification or non-classification
Based on the available in vitro genotoxicity data, trichloro(propyl)silane is not classified for mutagenicity according to Regulation (EC) No 1272/2008.
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