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EC number: 205-489-6 | CAS number: 141-57-1
There are no oral, inhalation or dermal reproductive toxicity studies available for trichloro(propyl)silane. Data waivers are in place for this endpoint.
Limited data are available regarding the reproduction and development of animals following oral, dermal or inhalation exposure to hydrogen chloride or hydrochloric acid, however, protons and chloride ions both exist as normal constituents of body fluid in animals, hence low concentrations of hydrogen chloride appear not to cause adverse effects in animals. Therefore hydrochloric acid would not contribute to any reproductive toxicity (fertility or developmental) effects at the dose levels tested.
There is an ongoing pre-natal developmental toxicity study, according to OECD TG 414 and in compliance with GLP, with the registered substance CAS 141-57-1. The study is expected to be finalised by January 2020, when the substance will be updated with the study results.
Dose range-finding studies for prenatal developmental toxicity studies (OECD 414) have also been conducted for another two chlorosilanes: dichloro(methyl)phenylsilane (CAS 149-74-6) and dichlorocyclohexylmethylsilane (CAS 5578-42-7). These dose range-finding studies have been added to this dataset to demonstrate consistency of effects among chlorosilane substances. For additional details please see the expert report attached to Section 13 of IUCLID (Weber, 2019). The summary also includes findings from a dose range-finding study for a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD 422) with tert-butylchlorodimethylsilane (CAS 18162-48-6), which has not been added to the dataset
The available data indicate that trichloro(propyl)silane does not need to be classified for toxicity to reproduction (fertility or developmental toxicity) according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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