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EC number: 296-866-4 | CAS number: 93164-85-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 9/16/85-1/24/86
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to the corresponding protocol and it is GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Protocol C 4A
- Deviations:
- no
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- -Physical state: white solid
- Storage: room temperature
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Harlan Labaratory Supply Company
- Weight at study initiation: 300-400 g
- Acclimation period: 4 days
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: Closed patch on clipped areas of intact skin
- Vehicle:
- other: mineral oil, acetone and 80/20 ETOH/H2O
- Concentration / amount:
- 7.5%, 2.5%, 0.75% w/v, 0.5%, 0.25% w/v, 7.5%, 2.5%, 0.75% w/v
Challengeopen allclose all
- Route:
- other: For patch placement
- Vehicle:
- other: mineral oil, acetone and 80/20 ETOH/H2O
- Concentration / amount:
- 7.5%, 2.5%, 0.75% w/v, 0.5%, 0.25% w/v, 7.5%, 2.5%, 0.75% w/v
- No. of animals per dose:
- 20 test animals, 10 control animals for rechallenge
Results and discussion
Any other information on results incl. tables
see executive summary
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- There were six responders (score >1) in a group of twenty guinea pigs previosly exposed to 2.5% of B0823-02 when challenged with 0.25% of B0823-02. There were no responders ion the control group. The test animals were rechallenged with 0.25% of B0823-02 and 1.0% of B0889-01. Testing with B0823-02 resulted in one responders in the test group and no responders in the control group. Testing with B0889-01 resulted in two responders in the test group and no responders in the control group. There was one responder (score >1) in a group of twenty guinea pigs previously exposed to 0.75% of B0823-02 when challenged with 0.25% of B0823-02. There were no responders in the control group. The test animals were rechallenged with 0.25% of B0823-02 and 1.0% of B0889-01. There were no responders from either test article. There were no responders in the control group. There were no respoders (score >1) in a group of twenty guinea pigs previously to 0.25% of B0823-02 when challenged with 0.25% of B0823-02. There were no responders in the control group. The test animals were rechallenged with 0.25% of B0823-02 and 1.0% of B0889-01. There were no responders from either test article. There were no responders in the control group.
- Executive summary:
A no-effect level of induction was established at 0.75% for B0823-02 in mineral oil following exposure to 0.25, 0.75 or 2.5% and a primary challenge of 0.25%. Six of 20 animals induced at 2.5% responded at challenge. Animals were rechallenged with B0823-02 (0.25%) and B0889-01 (1% in mineral oil). Some animals induced at 2.5% responded to both rechallenge substances (1/20 and 2/20, respectively). All other animals tested gave negative responses.
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