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Guidance on Safe Use

Guidance on Safe Use

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First-aid measures

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids.

Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Ingestion: Do NOT induce vomiting.  Allow the victim to rinse his mouth and then to drink 2-4 capfuls of water, and seek medical advice.

Inhalation: Remove from exposure to fresh air immediately.

Notes to physician: Treat symptomatically and supportively.

Fire-fighting measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved or equivalent, and full protective gear.

Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental release measures

Eye Protection: For small spills and leaks, wear a face shield with chemical splash goggles. The applicable European Standard can be found in EN 14605 and EN ISO 20345. For large spills and leaks, refer to respirator requirements.

Hand Protection: The use of chemical gauntlets (nitrile gloves) is required in the event of a spillage of leak. Gloves should be replaced immediately if signs of degradation are observed.

Skin: For small spills and leaks the use of overalls, a chemical resistant apron and rubber boots should be used, the applicable European standard can be found in EN ISO 20345. For large spills and leaks the use of a chemical resistant suit and rubber boots is required, the applicable European standard can be found in EN 14605 and EN ISO 20345.

Respirators: In the event of large spills and leaks, wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Handling and storage

Means of Rigorous Containment and Minimisation Technologies Recommended to the User of the Intermediate

The following operational conditions and risk management measures are recommended to downstream users of this transported isolated intermediate, to ensure that strictly controlled conditions to minimise worker and environmental exposure are achieved.

Rigorous Containment of the Substance by Technical Means

The transported isolated intermediate is supplied to downstream users in a an IMO Type 1 Tank (Stolt-Nielsen Transportation Group Ltd) storage vessel (Appendix 1). The substance should therefore be transferred into other closed containers for further processing and/or synthesis using compatible hose lines or piping with high integrity coupling. The manufacturing plant/apparatus engineering and systems must also prevent emissions of the intermediate to air and water.

It is recommended to each downstream user of this intermediate that the following operational procedures and failsafe mechanisms (or equivalent) are in place to minimise human and environmental exposure in the event of an accident:

• Material transfers via enclosed systems designed to prevent leaks (self-draining

transfer lines);

• High integrity methods of material loading and unloading (e.g. dry lock coupling,

vapour capture and recovery);

• Reactions vessels should be held under negative pressure. Any exhaust air from

reaction vessels should be filtered and incinerated. Vessels connected via fixed

pipes;

• Discharging should be designed to minimize emissions (e.g. into drums/kegs via

pneumatic filling heads and continuous liners);

• Plant designed to facilitate the draining and flushing of plant equipment items prior to

maintenance, with recycling and/or suitable disposal of wastes;

• High integrity (low emission) valve packing and flange seals;

• Low emission pumps (e.g. canned, magnetic, mechanical seals);

• Maximal use made of automated process control systems to minimise manual

interventions;

• Contained process sample systems (e.g. vented cabinets or sample bombs);

• Routine monitoring and inspection for leaks to reduce fugitive emissions;

• Systems are situated on concrete bases within a bund of capacity required for the

environmental permit held by the user. The tank floor and base sections of the walls

should be painted to prevent corrosion.

If a downstream user requires further handling stages before the intermediate is synthesised into a new chemical substance, the following containment strategy (or equivalent) should be adopted:

• Open Handling within Isolator

Transfer or handling of the intermediate takes place within an isolator. This generally

involves surrounding the transfer operation with a fixed, or flexible airtight barrier.

Containers of process material may be placed in or removed from the isolator only in

a way that does not compromise the integrity of the containment it provides. The

operator uses a glove-port to defect the handling of material (e.g. transfer).

Enclosures should be maintained under negative pressure to prevent leakage.

Containment air from the extraction system should be passed through a suitable safechange

HEPA filter before being exhausted outside the building.

Regular certification and testing of the filtration system is required.

Operator manipulates compounds via glove-box interface.

Procedural and Control Technologies to Minimise Emission and any Resulting Exposure

The following procedural and control technologies are recommended to users of this intermediate to minimize releases and any resulting exposure occurring despite rigorous containment by technical means:

• Air emission capture: All potential emissions to air are controlled by the use of air

emission captors and filtration. A HEPA-filter is recommended (or an equivalent

filter designed to trap small particles), and all air associated with the use of the

intermediate should be passed through the filter prior to discharge into the

atmosphere. All filters should be incinerated after use.

• Wastewater: Any wastewater containing residual amounts of this intermediate should

either be recycled (e.g. by distillation), or the wastewater should be incinerated.

It is the responsibility of each downstream user to monitor their implementation of procedural

controls to minimize emissions and resulting exposure to demonstrate that these procedures

ensure rigorous containment and minimisation of releases.

4.3. Handling of Substance by Trained Personnel

All workers handling this intermediate must be provided with the following:

• Training and information on process and task specific operating procedures,

appropriate precautions, working procedures during the malfunctioning of the process

and in accidental situations, and actions to be taken in order to safeguard themselves

and other workers at the workplace. Appropriate filing and documentation of training

shall be available on site

• Access to a Safety Data Sheet (SDS)

The above procedure should apply to all associated uses of the substance (including cleaning and maintenance).

Special Procedures Applied Before Cleaning and Maintenance

All equipment associated with this intermediate must be purged and washed prior to any manual cleaning and maintenance.  Any emissions or wastewater produced as a result of such purging and washing processes must be disposed of in accordance with details on wastewater disposal above, It is the responsibility of each downstream user of this chemical to ensure that the procedures applied before cleaning and maintenance are monitored to ensure that their efficiency adequately minimises any human or environmental exposure, and that any waste is treated accordingly to prevent environmental exposure.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:
2948
Shipping information
Proper shipping name and description:
3-trifluoromethylaniline
Language:
English
SpecialProvisionsopen allclose all

Inland waterway transport (UN RTDG/ADN(R))

UN number:
2948
Shipping information
Proper shipping name and description:
3-trifluoromethylaniline
Language:
English
Remarksopen allclose all

Marine transport (UN RTDG/IMDG)

UN number:
2948
Shipping information
Proper shipping name and description:
3-trifluoromethylaniline
Remarksopen allclose all

Air transport (UN RTDG/ICAO/IATA)

UN number:
2948
Shipping information
Proper shipping name and description:
3-trifluoromethylaniline
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Means of Rigorous Containment and Minimisation Technologies Recommended to the User of the Intermediate

The following operational conditions and risk management measures are recommended to downstream users of this transported isolated intermediate, to ensure that strictly controlled conditions to minimise worker and environmental exposure are achieved.

Rigorous Containment of the Substance by Technical Means

The transported isolated intermediate is supplied to downstream users in a an IMO Type 1 Tank (Stolt-Nielsen Transportation Group Ltd) storage vessel (Appendix 1). The substance should therefore be transferred into other closed containers for further processing and/or synthesis using compatible hose lines or piping with high integrity coupling. The manufacturing plant/apparatus engineering and systems must also prevent emissions of the intermediate to air and water.

It is recommended to each downstream user of this intermediate that the following operational procedures and failsafe mechanisms (or equivalent) are in place to minimise human and environmental exposure in the event of an accident:

• Material transfers via enclosed systems designed to prevent leaks (self-draining

transfer lines);

• High integrity methods of material loading and unloading (e.g. dry lock coupling,

vapour capture and recovery);

• Reactions vessels should be held under negative pressure. Any exhaust air from

reaction vessels should be filtered and incinerated. Vessels connected via fixed

pipes;

• Discharging should be designed to minimize emissions (e.g. into drums/kegs via

pneumatic filling heads and continuous liners);

• Plant designed to facilitate the draining and flushing of plant equipment items prior to

maintenance, with recycling and/or suitable disposal of wastes;

• High integrity (low emission) valve packing and flange seals;

• Low emission pumps (e.g. canned, magnetic, mechanical seals);

• Maximal use made of automated process control systems to minimise manual

interventions;

• Contained process sample systems (e.g. vented cabinets or sample bombs);

• Routine monitoring and inspection for leaks to reduce fugitive emissions;

• Systems are situated on concrete bases within a bund of capacity required for the

environmental permit held by the user. The tank floor and base sections of the walls

should be painted to prevent corrosion.

If a downstream user requires further handling stages before the intermediate is synthesised into a new chemical substance, the following containment strategy (or equivalent) should be adopted:

• Open Handling within Isolator

Transfer or handling of the intermediate takes place within an isolator. This generally

involves surrounding the transfer operation with a fixed, or flexible airtight barrier.

Containers of process material may be placed in or removed from the isolator only in

a way that does not compromise the integrity of the containment it provides. The

operator uses a glove-port to defect the handling of material (e.g. transfer).

Enclosures should be maintained under negative pressure to prevent leakage.

Containment air from the extraction system should be passed through a suitable safechange

HEPA filter before being exhausted outside the building.

Regular certification and testing of the filtration system is required.

Operator manipulates compounds via glove-box interface.

Procedural and Control Technologies to Minimise Emission and any Resulting Exposure

The following procedural and control technologies are recommended to users of this intermediate to minimize releases and any resulting exposure occurring despite rigorous containment by technical means:

• Air emission capture: All potential emissions to air are controlled by the use of air

emission captors and filtration. A HEPA-filter is recommended (or an equivalent

filter designed to trap small particles), and all air associated with the use of the

intermediate should be passed through the filter prior to discharge into the

atmosphere. All filters should be incinerated after use.

• Wastewater: Any wastewater containing residual amounts of this intermediate should

either be recycled (e.g. by distillation), or the wastewater should be incinerated.

It is the responsibility of each downstream user to monitor their implementation of procedural

controls to minimize emissions and resulting exposure to demonstrate that these procedures

ensure rigorous containment and minimisation of releases.

4.3. Handling of Substance by Trained Personnel

All workers handling this intermediate must be provided with the following:

• Training and information on process and task specific operating procedures,

appropriate precautions, working procedures during the malfunctioning of the process

and in accidental situations, and actions to be taken in order to safeguard themselves

and other workers at the workplace. Appropriate filing and documentation of training

shall be available on site

• Access to a Safety Data Sheet (SDS)

The above procedure should apply to all associated uses of the substance (including cleaning and maintenance).

Special Procedures Applied Before Cleaning and Maintenance

All equipment associated with this intermediate must be purged and washed prior to any manual cleaning and maintenance.  Any emissions or wastewater produced as a result of such purging and washing processes must be disposed of in accordance with details on wastewater disposal above, It is the responsibility of each downstream user of this chemical to ensure that the procedures applied before cleaning and maintenance are monitored to ensure that their efficiency adequately minimises any human or environmental exposure, and that any waste is treated accordingly to prevent environmental exposure.

Describe Activity and Type of PPE in Case of Accidents, Incidents, Maintenance and Cleaning Activities

In the case of accidents, incidents, maintenance and cleaning activities, workers must ensure that the appropriate level of PPE is utilized to prevent occupational exposure.

Spills and Leaks

Eye Protection: For small spills and leaks, wear a face shield with chemical splash goggles.

The applicable European Standard can be found in EN 14605 and EN ISO 20345. For large

spills and leaks, refer to respirator requirements.

Hand Protection: The use of chemical gauntlets (nitrile gloves) is required in the event of a

spillage of leak. Gloves should be replaced immediately if signs of degradation are observed.

Skin: For small spills and leaks the use of overalls, a chemical resistant apron and rubber

boots should be used, the applicable European standard can be found in EN ISO 20345. For

large spills and leaks the use of a chemical resistant suit and rubber boots is required, the

applicable European standard can be found in EN 14605 and EN ISO 20345.

Respirators: In the event of large spills and leaks, wear a NIOSH/MSHA or European

Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with

emergency escape provisions.

Maintenance and Cleaning Activities

Eye Protection: If maintaining equipment (e.g. pumps) wear a face shield with chemical

splash goggles. The applicable European Standard can be found in EN 14605 and EN ISO

20345. If maintenance or cleaning activities takes place in an enclosed space (e.g. reactor,

small room) refer to respirator requirements.

Hand Protection: The use of chemical gauntlets (e.g. nitrile gloves) is required. Gloves

should be replaced immediately if signs of degradation are observed.

Skin: If maintaining equipment (e.g. pumps) the use of overalls, a chemical resistant apron

and rubber boots is required, the applicable European standard can be found in EN ISO

20345. If maintenance or cleaning activities takes place in an enclosed space (e.g. reactor,

small room) the use of a chemical resistant suit and rubber boots is required, the applicable

European standard can be found in EN 14605 and EN ISO 20345.

Respirators: If maintenance or cleaning activities takes place in an enclosed space (e.g.

reactor, small room) wear a NIOSH/MSHA or European Standard EN 149 approved fullfacepiece

airline respirator in the positive pressure mode with emergency escape provisions.

Waste Information

All waste generated should be treated on-site. Waste may be generated during processing and

synthesis and cleaning and maintenance of equipment. Waste will be in the form of air

emissions and wastewater.

Emissions via air are captured using air filtration before the air is discharged into the

environment. All filters should be incinerated after use.

Any wastewater produced containing residual amounts of the chemical substance will be

recycled (e.g. by distillation) or incinerated.

It is the responsibility of each downstream user to ensure that their method and efficiency of

waste treatment ensures rigorous containment and minimisation of release

Stability and reactivity

Chemical stability: Stable under normal temperature and pressure.

Incompatible with other materials: Strong oxidising agents.

Hazardous decomposition products: Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride, nitrogen.

Disposal considerations

Disposal should be conducted in accordance with local, regional or national regulations.

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