Ethyl methacrylate

Long-term toxicity to aquatic invertebrates

Description of key information

Long-term daphnia: 21-day NOEC 18 mg/L (Daphnia magna)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

18 mg/L

Additional information

In a valid OECD 211, the 21-day LOEC for Daphnia magna was 31 mg/L; the NOEC for reproduction was 18 mg/L.

For ethyl methacrylate the long-term study in Daphnia magna showed a LOEC of 31 mg/L and a NOEC for reproduction of 18 mg/L. Data are available for the lower alkyl methacrylates category which indicate a trend of increasing toxicity (21 -d NOEC/LOEC) from the acid and the methyl ester to the ester with the longest side chain in the category, 2‑EHMA. See the following table:

Summary of long-term effects on invertebrates

Ester	Invertebrate Species	NOEC / LOEC (mg/l)	Exposure time	Study Type	Remarks	Reference
MAA	D. magna	53^a/ 110^a	21 days	OECD 202 p. 2 (flow-through)	Rel. 1	Putt, 1995a
MMA	D. magna	37^a/68^a	21 days	OECD 202 p. 2 (flow-through)	Rel. 1	Putt, 1995b
EMA	D. magna	18^a/31^a	21 days	OECD 202 p. 2 (flow-through)	Rel. 1	Putt, 1995c
n-BMA	D. magna	2.6^a/4.9^a	21 days	OECD 202 p. 2 (flow-through)	Rel. 1	Putt, 1995d
	D. magna	1.1^a/ 3.4^a	21 days	OECD 202 p. 2 (semi-static, closed vessels)^c	Rel. 1	MoE, 1998a
2-EHMA	D. magna	0.29^a, c/ 0.64^a, c	21 days	OECD 202 p. 2 (semi-static, closed vessels)	Rel. 2	MoE, 1998b
	D. magna	0.105^a/ 0.219^a	21 days	OECD 211 (semi-static, closed vessels)	Rel. 1	Schäfers, 2004b

^abased on measured concentrations;^bbased on analytically confirmed nominal concentrations;^cdispersant used, but NOEC and LOEC within the range of solubility