Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

All available Ames tests, the chromosomal aberration tests (CA) in mammalian cells, and a mammalian cell gene mutation assay (HPRT test) using Chinese HamsterOvary cells are negative.

A not assignable (secondary literature) chromosome aberration test in rat bone marrow cells in vivo was also negative

Short description of key information:
An Ames tests, a cytogenetic assay for chromosomal aberration and mammalian cell gene mutation assay (CHO/HGPRT) are available

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

From the available data a classification is not justified because all genetic toxicity tests were negative